Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19.
Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19.
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DOI：
10.1208/s12248-020-00532-2
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发表时间：
2021-01-05
期刊：
影响因子：
--
通讯作者：
Minko T
中科院分区：
文献类型：
--
作者：
Majumder J;Minko T
由严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）持续大流行，已对全球范围内的公共卫生构成严重威胁，越来越多的国家有数百万人面临风险。虽然目前尚无临床批准的抗病毒药物和疫苗用于COVID-19，但正在尝试对几种已知的抗病毒药物及其组合进行临床试验，并在确诊的COVID-19患者中开发疫苗。本综述重点介绍COVID-19诊断和治疗的最新方法。我们总结了抗病毒药物、疫苗、抗SARS-CoV-2抗体治疗和恢复期血浆治疗等常规治疗方法的最新进展，这些治疗方法目前正在广泛研究和临床试验中。针对COVID-19，还讨论了基于纳米颗粒的治疗和诊断方法的发展。我们评估了最近的文献数据，并对当前的发展和未来的前景进行了总结。
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a serious public health threat worldwide with millions of people at risk in a growing number of countries. Though there are no clinically approved antiviral drugs and vaccines for COVID-19, attempts are ongoing for clinical trials of several known antiviral drugs, their combination, as well as development of vaccines in patients with confirmed COVID-19. This review focuses on the latest approaches to diagnostics and therapy of COVID-19. We have summarized recent progress on the conventional therapeutics such as antiviral drugs, vaccines, anti-SARS-CoV-2 antibody treatments, and convalescent plasma therapy which are currently under extensive research and clinical trials for the treatment of COVID-19. The developments of nanoparticle-based therapeutic and diagnostic approaches have been also discussed for COVID-19. We have assessed recent literature data on this topic and made a summary of current development and future perspectives.
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发表时间：
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期刊：
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