Compliance with Saliva Collection Protocol in Healthy Volunteers: Strategies for Managing Risk and Errors.
Compliance with Saliva Collection Protocol in Healthy Volunteers: Strategies for Managing Risk and Errors.
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DOI：
10.7150/ijms.25146
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发表时间：
2018
影响因子：
3.6
通讯作者：
Chae HJ
中科院分区：
文献类型：
--
作者：
Bhattarai KR;Kim HR;Chae HJ
唾液生物科学技术，如电泳，广泛应用于诊断全身健康状况。使用唾液样本的诊断已经成为优选的技术，因为样本容易收集并且该方法便宜且非侵入性。唾液诊断甚至已被确定为血清蛋白生物标志物的潜在替代品。然而，收集唾液的最佳方案尚未建立。在许多科学环境中，例如随机对照试验，在处理来自健康志愿者的样本时经常发生采样和统计错误。这些错误可能是由于志愿者的心理行为、受试者不依从、问卷特征、采集方法和/或样本处理所致。本文综述的目的是概述管理风险因素的策略，并尽量减少健康志愿者唾液采集过程中的采样误差。
Salivary bioscience technologies such as electrophoresis are widely applied for diagnosing systemic health status. Diagnosis using a saliva sample has emerged as a preferred technique since the sample is easy to collect and the method is inexpensive and non-invasive. Salivary diagnostics have even been identified as potential substitutes for serum protein biomarkers. However, the optimal protocol for collecting saliva has not yet been established. In many scientific settings, such as randomized controlled trials, sampling and statistical errors often occur when handling samples from healthy volunteers. These errors can be due to the psychological behavior of the volunteers, subject nonadherence, questionnaire characteristics, collection methods, and/or sample processing. The purpose of the review presented here is to outline the strategies for managing the risk factors and to minimize the sampling errors during saliva collection in healthy volunteers.
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影响因子：
1.3
作者：
Arhakis, Aristidis;Karagiannis, Vasilis;Kalfas, Sotirios
通讯作者：
Kalfas, Sotirios
与唾液流量，pH，缓冲能力和口干的迹象相关的口腔干燥迹象。
影响因子：
2.9
作者：
Farsi, Najat M A
通讯作者：
Farsi, Najat M A
影响因子：
2.5
作者：
Granger, Douglas A.;Johnson, Sara B.;Schumann, Lynette Lau
通讯作者：
Schumann, Lynette Lau
影响因子：
3.7
作者：
Goodson JM;Kantarci A;Hartman ML;Denis GV;Stephens D;Hasturk H;Yaskell T;Vargas J;Wang X;Cugini M;Barake R;Alsmadi O;Al-Mutawa S;Ariga J;Soparkar P;Behbehani J;Behbehani K;Welty F
通讯作者：
Welty F
影响因子：
7.6
作者：
DENNY, PC;DENNY, PA;TABAK, LA
通讯作者：
TABAK, LA