Non-Thermal Effects of Near-Infrared Irradiation on Melanoma
Non-Thermal Effects of Near-Infrared Irradiation on Melanoma
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近红外照射对黑色素瘤的非热效应
DOI：
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
K. Matsuo
中科院分区：
文献类型：
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作者：
Yohei Tanaka;K. Matsuo
恶性黑色素瘤被认为是最具侵袭性的皮肤肿瘤。在过去的几十年里，黑色素瘤的发病率在全球范围内稳步上升。发生黑色素瘤的风险包括内在因素和环境因素。内在因素通常包括家族史和遗传基因，而最相关的环境因素是阳光暴晒。暴露于紫外线(UV)辐射是最重要的环境致癌物质(Travers等人，2008年)，并在黑色素瘤的发展中起着重要作用(Wolf等人，1994)。防晒霜减少紫外线辐射对人体皮肤的影响(Ananthaswamy等人，1997年)。然而，防晒霜未能预防紫外线辐射引起的黑色素瘤的增加(Wolf等人，1994)。各种紫外线阻挡材料，如防晒霜、薄膜、油漆和纤维，经常被用来防止紫外线照射对皮肤的损害。尽管世界各地的人都在使用各种防晒霜，但仍会发生不必要的生物影响，如玫瑰红斑、红斑、长期血管扩张、肌肉变薄和下垂(Tanaka等人，2010c)。大多数防晒霜只能阻挡紫外线，而不能阻挡可见光或近红外(NIR)辐射。到达人体皮肤的阳光含有6.8%的紫外光、38.9%的可见光和54.3%的红外线(IR)辐射组成的太阳能(Kochevar等人，1999年)。除了天然近红外之外，人类皮肤越来越多地暴露于来自医疗设备和电器的人造近红外(Schieke等人，2003年；Schroeder等人，2008年)。因此，我们暴露在大量的近红外辐射中。紫外线和可见光辐射都被黑色素减弱(Anderson&Parrish，1981)，而近红外可以深入人体组织，在那里它可以引起光化学变化(Karu，1999)。我们以前曾报道过近红外透过皮肤，并被皮肤表面的汗水、真皮中的水吸收(Tanaka等人。(2009a，2009b)，血管扩张中的血红蛋白(Tanaka等人，2009b，2011c)，浅肌肉中的肌红蛋白(Tanaka等人，2010c)，骨皮质团块，并被脂肪细胞分散(Tanaka等人，2011b)。近红外辐射通过细胞凋亡诱导链断裂和细胞死亡(Tirlapur&Konig，2001)以及癌细胞和骨髓细胞的细胞死亡(Tanaka等人，2010b，2011b)。此外，近红外照射被用作治疗伤口愈合的一种选择。
Malignant melanoma is considered to be the most aggressive form of skin neoplasms. Over the past few decades, the incidence rate of melanoma has steadily risen throughout the world. The risks of developing melanoma consist of intrinsic and environmental factors. Intrinsic factors generally include a family history and an inherited genotype, while the most relevant environmental factor is sun exposure. Exposure to ultraviolet (UV) radiation is the most important environmental carcinogen (Travers et al., 2008) and plays a significant role in the development of melanoma (Wolf et al., 1994). Sunscreens reduce the effects of UV radiation on human skin (Ananthaswamy et al., 1997). Nevertheless, sunscreens have failed to protect against an increase in UV radiation-induced melanomas (Wolf et al., 1994). Various kinds of UV blocking materials, such as sunblocks, films, paints, and fibers are often used to prevent skin damage from UV exposure. Although individuals all over the world use various kinds of sunscreens, unwanted biological influences such as rosasea, erythema ab igne, long-term vasodilation, muscle thinning, and sagging still occur (Tanaka et al., 2010c). Most sunscreens can only block UV and not visible light or near-infrared (NIR) radiation. Sunlight that reaches the human skin contains solar energy composed of 6.8% UV light, 38.9% visible light, and 54.3% infrared (IR) radiation (Kochevar et al., 1999). In addition to natural NIR, human skin is increasingly exposed to artificial NIR from medical devices and from electrical appliances (Schieke et al., 2003; Schroeder et al., 2008). Thus, we are exposed to tremendous amounts of NIR. Both UV and visible light radiation are attenuated by melanin (Anderson & Parrish, 1981), whereas NIR can penetrate deep into human tissue where it can cause photochemical changes (Karu, 1999). We previously reported that NIR penetrates the skin and is absorbed by sweat on the skin surface, water in the dermis (Tanaka et al. 2009a, 2009b), hemoglobin in dilated vessels (Tanaka et al., 2009b, 2011c), myoglobin in the superficial muscle (Tanaka et al., 2010c), bone cortical mass, and is scattered by adipose cells (Tanaka et al., 2011b). NIR irradiation induces strand breaks and cell death by apoptosis (Tirlapur & Konig, 2001) as well as the cell death of cancer cells and bone marrow cells (Tanaka et al., 2010b, 2011b). In addition, NIR irradiation is used as a therapeutic option for the treatment of wound healing
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影响因子：
--
作者：
Tafur, Joseph;Mills, Paul J.
通讯作者：
Mills, Paul J.
DOI：
--
发表时间：
--
期刊：
Environmental Science and Pollution Research International
影响因子：
--
作者：
P. Wust;B. Hildebrandt;G. Sreenivasa;B. Rau;J. Gellermann;H. Riess;R. Felix;P. Schlag
通讯作者：
P. Wust;B. Hildebrandt;G. Sreenivasa;B. Rau;J. Gellermann;H. Riess;R. Felix;P. Schlag
影响因子：
14.5
作者：
Bakay, M;Wang, ZY;Hoffman, EP
通讯作者：
Hoffman, EP
影响因子：
6.5
作者：
ANDERSON, RR;PARRISH, JA
通讯作者：
PARRISH, JA