Orthodontic treatment-induced temporal alteration of jaw-opening reflex excitability.
Orthodontic treatment-induced temporal alteration of jaw-opening reflex excitability.
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正畸治疗引起的张颌反射兴奋性的时间改变。
DOI：
10.1152/jn.00379.2017
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发表时间：
2017
期刊：
影响因子：
2.5
通讯作者：
Suda N
中科院分区：
文献类型：
--
作者：
Sasaki A;Hasegawa N;Adachi K;Sakagami H;Suda N
正畸治疗过程中口面运动功能的损害需要得到解决，因为大多数正畸患者都会经历疼痛，疼痛会影响运动兴奋性。在本研究中，开颚反射兴奋性的时间变化进行了调查，以确定是否正畸治疗影响口面运动功能。在对右侧牙齿施加正畸力后1天（D1）、3天（D3）和7天（D 7），评价由电刺激牙龈诱发的并在双侧前二腹肌中记录的开颌反射的兴奋性;形态学特征（例如，破骨细胞发生和牙齿移动）。为了阐明正畸治疗引起的口面运动兴奋性改变的潜在机制，给予镇痛药1天。在D1和D3，正畸治疗显着降低阈值诱导开颌反射，但显着增加阈值在D 7。还评估了下颌张开反射的其他参数（例如，二腹肌前肌活动的潜伏期、持续时间和曲线下面积），只有D1组的潜伏期与其他组有显著性差异。开颌反射兴奋性的时间变化与形态特征的变化显著相关。阿司匹林（300 mg·kg-1·day-1）显著增加了诱导张口反射的阈值，而较低剂量（75-150 mg·kg-1·day-1）的阿司匹林或对乙酰氨基酚（300 mg·kg-1·day-1）未能改变张口反射的兴奋性。这些结果表明，增加的下颌张开反射兴奋性可以诱导急性正畸治疗，可能通过环氧合酶activation.NEW & NOTEWORTHIT是众所周知的，运动功能受到疼痛，但正畸治疗相关的疼痛三叉神经运动兴奋性的影响尚未完全了解。我们发现，在正畸治疗期间，三叉神经运动兴奋性急剧增加，然后在一周内下降。由于三叉神经运动功能的改变可以定量评价开颌反射的兴奋性，本动物模型可能是有用的，以寻找替代方法来减轻正畸疼痛。
The impairment of orofacial motor function during orthodontic treatment needs to be addressed, because most orthodontic patients experience pain and motor excitability would be affected by pain. In the present study, the temporal alteration of the jaw-opening reflex excitability was investigated to determine if orthodontic treatment affects orofacial motor function. The excitability of jaw-opening reflex evoked by electrical stimulation on the gingiva and recorded bilaterally in the anterior digastric muscles was evaluated at 1 (D1), 3 (D3), and 7 days (D7) after orthodontic force application to the teeth of right side; morphological features (e.g., osteoclast genesis and tooth movement) were also evaluated. To clarify the underlying mechanism of orthodontic treatment-induced alteration of orofacial motor excitability, analgesics were administrated for 1 day. At D1 and D3, orthodontic treatment significantly decreased the threshold for inducing the jaw-opening reflex but significantly increased the threshold at D7. Other parameters of the jaw-opening reflex were also evaluated (e.g., latency, duration and area under the curve of anterior digastric muscles activity), and only the latency of the D1 group was significantly different from that of the other groups. Temporal alteration of the jaw-opening reflex excitability was significantly correlated with changes in morphological features. Aspirin (300 mg·kg−1·day−1) significantly increased the threshold for inducing the jaw-opening reflex, whereas a lower dose (75–150 mg·kg−1·day−1) of aspirin or acetaminophen (300 mg·kg−1·day−1) failed to alter the jaw-opening reflex excitability. These results suggest that an increase of the jaw-opening reflex excitability can be induced acutely by orthodontic treatment, possibly through the cyclooxygenase activation.NEW & NOTEWORTHYIt is well known that motor function is affected by pain, but the effect of orthodontic treatment-related pain on the trigeminal motor excitability has not been fully understood. We found that, during orthodontic treatment, trigeminal motor excitability is acutely increased and then decreased in a week. Because alteration of trigeminal motor function can be evaluated quantitatively by jaw-opening reflex excitability, the present animal model may be useful to search for alternative approaches to attenuate orthodontic pain.
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