Dual frequency method for simultaneous translation and real-time imaging of ultrasound contrast agents within large blood vessels.
Dual frequency method for simultaneous translation and real-time imaging of ultrasound contrast agents within large blood vessels.
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DOI：
10.1016/j.ultrasmedbio.2009.07.003
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发表时间：
2009-12
影响因子：
2.9
通讯作者：
Hossack, John A.
中科院分区：
文献类型：
--
作者：
Patil, Abhay V.;Rychak, Joshua J.;Allen, John S.;Klibanov, Alexander L.;Hossack, John A.
关键词：
提出了一种用于微气泡同时平移和选择性实时成像的双频激励方法。该方法可以区分来自自由流动和静态微泡的信号。该方法是在一个宽带线阵可编程扫描器上实现的。可编程接口允许声学参数和孔径属性的动态变化，使得该方法能够应用于位于不同深度的大血管。通过量化方法对各种声学、微泡和流体流动参数的灵敏度，在体外（血管直径2 mm）评价了该方法的性能。观察到静态微泡响应在微泡群体的近似共振频率下最大化（从库尔特计数器测量估计），因此表明需要双频激励。静态微泡信号随着中心线流速的增加（2.65-15.9 cm/s）从25 dB下降至12 dB;表明流速的适用范围。静态微泡信号的最大强度与微泡浓度的变化成比例。静态微泡信号的增长率与微泡浓度无关。推导出静态微泡信号的增量率主要是脉冲频率的函数，而最大静态微泡信号强度取决于三个参数：a）脉冲频率，B）流速，和c）微泡浓度。所提出的双频序列可以使得能够应用辐射力以优化靶向成像的效果并调节具有高流速的大血管中的药物递送。
A dual frequency excitation method for simultaneous translation and selective real-time imaging of microbubbles is presented. The method can distinguish signals originating from free flowing and static microbubbles. This method is implemented on a programmable scanner with a broadband linear array. The programmable interface allows for dynamic variations in the acoustic parameters and aperture attributes, enabling application of this method to large blood vessels located at varying depths. The performance of the method was evaluated in vitro (vessel diameter 2 mm) by quantifying the sensitivity of the method to various acoustic, microbubble, and fluid flow parameters. It was observed that the static microbubble response maximized at the approximate resonance frequency of the microbubble population (estimated from a coulter counter measurement), thus signifying the need for dual frequency excitation. The static microbubble signal declined from 25 to 12 dB with increasing centerline flow velocities (2.65-15.9 cm/s); indicating applicable range of flow velocities. The maximum intensity of the static microbubbles signal scaled with variations in the microbubble concentration. The rate of increment of static microbubble signal was independent of microbubble concentration. It was deduced that the rate of increment of the static microbubble signal is primarily a function of the pulse frequency, whereas the maximum static microbubble signal intensity is dependent on three parameters: a) the pulse frequency, b) the flow velocity, and c) the microbubble concentration. The proposed dual frequency sequence may enable application of radiation force for optimizing the effect of targeted imaging and modulating drug delivery in large blood vessels with high flow velocities.
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DOI：
10.1109/tuffc.2005.1417264
发表时间：
2005-03-01
影响因子：
3.6
作者：
Rychak, JJ;Klibanov, AL;Hossack, JA
通讯作者：
Hossack, JA
影响因子：
2.9
作者：
Rychak, Joshua J.;Klibanov, Alexander L.;Hossack, John A.
通讯作者：
Hossack, John A.
影响因子：
2.4
作者：
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通讯作者：
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影响因子：
37.8
作者：
Lindner, JR;Song, J;Ley, K
通讯作者：
Ley, K
影响因子：
37.8
作者：
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通讯作者：
Ramage, D