Sex hormone mediated change on flexion reflex.
Sex hormone mediated change on flexion reflex.
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DOI：
10.3389/fnins.2023.1263756
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发表时间：
2023
影响因子：
4.3
通讯作者：
Dhaher, Yasin Y.
中科院分区：
文献类型：
--
作者：
Soedirdjo, Subaryani D. H.;Chung, Yu-Chen;Dhaher, Yasin Y.
已有研究表明，雌激素和孕激素受体在脊髓中表达，因此，它们的浓度波动可能会影响脊髓网络，调节运动的控制。在此，我们以屈曲反射网络为模型系统，评价了性激素对多突触脊髓网络的神经调节作用。2 4例健康月经过多妇女(年龄21~37 )，每隔一天检查一次月经周期。检测时采集血清雌二醇和孕酮。胫前肌屈曲反射是通过直接向胫后神经或足底皮肤传入发出无害的电刺激而引起的。对每个月经周期阶段进行分析：卵泡期和黄体期。无论是卵泡期还是黄体期，雌二醇或孕酮浓度的升高与反射持续时间或均方根(RMS)幅度无关。在黄体期，雌二醇浓度的升高与反射潜伏期的延长有关(b = 0.23，p = 0.038)。雌二醇与孕酮的交互作用达到显著水平(b = −0.017，p = 0.081)。这些结果突出了雌二醇和孕酮的潜在协同作用，并可能为观察到的调节作用提供间接的确证证据。
It has been shown that estrogen and progesterone receptors are expressed in the spinal cord; therefore, fluctuation in their concentrations may affect the spinal network and modulate the control of movement. Herein, we assessed the neuro-modulatory effect of sex hormones on the polysynaptic spinal network by using a flexion reflex network as a model system. Twenty-four healthy eumenorrheic women (age 21–37 years) were tested every other day for one menstrual cycle. Serum estradiol and progesterone were acquired at the time of testing. The flexion reflex of the tibialis anterior was elicited by sending an innocuous electrical stimulus directly to the posterior tibial nerve or plantar cutaneous afferent. Analyses were performed for each menstrual cycle phase: the follicular phase and the luteal phase. Increases in estradiol or progesterone concentrations were not associated with reflex duration or root mean squared (RMS) amplitude in either the follicular or luteal phases. In the luteal phase, an increase in the estradiol concentration was associated with a longer latency of the reflex (b = 0.23, p = 0.038). The estradiol × progesterone interaction was found towards significance (b = −0.017, p = 0.081). These results highlight the potential synergistic effect of estradiol and progesterone and may provide indirect confirmatory evidence of the observed modulatory effect.
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影响因子：
2.9
作者：
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