N-methyl-N-nitrosourea-induced mammary carcinogenesis is promoted by short-term treatment with estrogen and progesterone mimicking pregnancy in aged female Lewis rats.
N-methyl-N-nitrosourea-induced mammary carcinogenesis is promoted by short-term treatment with estrogen and progesterone mimicking pregnancy in aged female Lewis rats.
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N-甲基-N-亚硝基脲诱导的乳腺癌的发生是通过模拟老年雌性Lewis大鼠妊娠的短期雌激素和孕激素治疗来促进的。
DOI：
10.3892/or.18.2.337
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发表时间：
2007
期刊：
影响因子：
4.2
通讯作者：
A. Tsubura
中科院分区：
文献类型：
--
作者：
R. Tsukamoto;Takako Mikami;Katsuaki Miki;N. Uehara;T. Yuri;Y. Matsuoka;K. Okazaki;A. Tsubura
我们研究了短期雌激素和孕激素治疗模拟老年雌性刘易斯大鼠妊娠对N-甲基-N-亚硝基脲（MNU）诱导的乳腺癌发展的影响。在7周龄时对大鼠单次腹腔注射20 mg/kg MNU，在24周龄时对其中一半大鼠皮下植入含有0.5 mg 17 β-雌二醇和32.5 mg孕酮（E/P）的21天释放颗粒。然后监测大鼠乳腺肿瘤的发生。当最大的乳腺肿瘤直径>或= 1 cm时，或当大鼠达到48周龄时，处死大鼠。与E/P未处理的大鼠相比，短期E/P处理后MNU诱导的乳腺癌的发展加速：>或= 1 cm乳腺癌的发生率倾向于增加（60 vs. 44%）;潜伏期倾向于缩短（28.7 vs. 34.6周）;癌症多样性（每只大鼠所有大小的癌症数量）显著增加（1.8 vs. 0.8）。在E/P处理的大鼠中，粉刺坏死是常见的，雌激素受体和/或孕激素受体阴性乳腺癌的发病率显着增加。早期足月妊娠或短期激素治疗模仿怀孕可能会抑制乳腺癌的风险，但激素暴露的年龄是一个关键因素，因为激素暴露模仿怀孕的老年人可能会产生与年轻人相反的效果。
We examined the effects of short-term estrogen and progesterone treatment mimicking pregnancy in aged female Lewis rats on the development of N-methyl-N-nitrosourea (MNU)-induced mammary carcinoma. Rats were administered a single intraperitoneal injection of 20 mg/kg MNU at 7 weeks of age and half of those rats were administered a subcutaneously implanted 21-day release pellet containing 0.5 mg 17beta-estradiol and 32.5 mg progesterone (E/P) at 24 weeks of age. The rats were then monitored for the occurrence of mammary tumors. Rats were sacrificed when the largest mammary tumor became > or = 1 cm in diameter, or when the rat reached 48 weeks of age. Development of MNU-induced mammary carcinomas was accelerated after short-term E/P treatment, compared with E/P-untreated rats: the incidence of > or = 1-cm mammary carcinomas tended to increase (60 vs. 44%); the latency tended to shorten (28.7 vs. 34.6 weeks); and cancer multiplicity (number of all-sized carcinomas per rat) significantly increased (1.8 vs. 0.8). In E/P-treated rats, comedo necrosis was frequently seen and the incidence of estrogen receptor and/or progesterone receptor-negative mammary carcinomas was significantly increased. Early age at full-term pregnancy or short-term hormone treatment mimicking pregnancy may suppress the risk of breast cancer, but the age of hormone exposure is a crucial factor, because hormone exposure mimicking pregnancy in aged individuals may exert effects opposite of those exerted in younger individuals.
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DOI：
10.1093/jnci/71.3.625
发表时间：
1983-09
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
C. Grubbs;D. L. Hill;K. McDonough;J. Peckham
通讯作者：
C. Grubbs;D. L. Hill;K. McDonough;J. Peckham
N-甲基-N-亚硝基脲在用表皮生长因子治疗的卵巢切除大鼠中诱导乳腺癌。
影响因子：
4.7
作者：
Chou,YC;Guzman,RC;Swanson,SM;Yang,J;Lui,HM;Wu,V;Nandi,S
通讯作者：
Nandi,S
妊娠和哺乳期对雌性 Lewis 大鼠 N-甲基-N-亚硝基脲诱发乳腺癌的保护作用。
影响因子：
4.7
作者：
Yang,J;Yoshizawa,K;Nandi,S;Tsubura,A
通讯作者：
Tsubura,A
DOI：
10.1073/pnas.96.5.2520
发表时间：
1999-03-02
影响因子：
11.1
作者：
Guzman, RC;Yang, J;Nandi, S
通讯作者：
Nandi, S
经产大鼠在用各种促乳腺激素治疗后，对化学诱发的乳腺癌恢复了高度的易感性。
影响因子：
4.7
作者：
Thordarson,G;VanHorn,K;Guzman,RC;Nandi,S;Talamantes,F
通讯作者：
Talamantes,F