Therapeutic effects of diclofenac, pregabalin, and duloxetine on disuse-induced chronic musculoskeletal pain in rats.
Therapeutic effects of diclofenac, pregabalin, and duloxetine on disuse-induced chronic musculoskeletal pain in rats.
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DOI：
10.1038/s41598-018-21429-3
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发表时间：
2018-02-19
影响因子：
4.6
通讯作者：
Sato J
中科院分区：
文献类型：
--
作者：
Ohmichi Y;Ohmichi M;Murai N;Yasui M;Takeshita N;Oshibuchi H;Naito M;Nakano T;Sato J
本研究的目的是通过评价双氯芬酸（NSAID）、普瑞巴林（一种钙通道α2δ抑制剂）和度洛沙坦（SNRI）治疗急性和慢性镜像肌肉痛觉过敏的慢性石膏后疼痛（CPCP）大鼠的肌肉痛觉过敏特征的药理学行为，阐明废用性肌肉痛觉过敏的机制。石膏固定2周后，CPCP大鼠同侧比目鱼肌和腓肠肌的峰值横截面积和肌肉湿重比未治疗大鼠显著降低。组织学结果显示废用诱导的肌肉萎缩CPCP大鼠。急性期和慢性期CPCP大鼠的血液生化指标与未治疗组相比无显著性差异。双氯芬酸和普瑞巴林治疗组在急性或慢性肌肉痛觉过敏方面没有表现出改善。相比之下，度洛西汀治疗组对急性肌肉痛觉过敏有改善，但对同侧或对侧的慢性肌肉痛觉过敏没有明显影响。鞘内注射μ-阿片受体激动剂DAMGO可逆转慢性肌肉痛觉过敏。结果表明CPCP大鼠的慢性肌肉痛觉过敏不是由炎症机制引起的，并且只有很低的可能性是由神经病理机制引起的。
The aim of this study was to clarify the mechanism of disuse-induced muscle hyperalgesia through the evaluation of the pharmacological behaviour of muscle hyperalgesia profiles in chronic post-cast pain (CPCP) rats with acute and chronic-phase mirror-image muscle hyperalgesia treated with diclofenac (NSAID), pregabalin (an inhibitor of Ca2+ channel α2δ), and duloxetine (SNRI). After 2 weeks of cast immobilization, the peak cross-sectional area and muscle wet weight of the ipsilateral soleus and gastrocnemius muscles decreased more significantly in CPCP rats than in untreated rats. Histological findings revealed disuse-induced muscle atrophy in CPCP rats. The blood biochemical parameters of CPCP rats in acute and chronic phases did not differ significantly from those of untreated rats. The diclofenac and pregabalin-treated groups exhibited no improvement in acute or chronic muscle hyperalgesia. In contrast, the duloxetine-treated group exhibited an improvement in acute muscle hyperalgesia, but showed no apparent effect on chronic muscle hyperalgesia on ipsilateral or contralateral sides. However, the chronic muscle hyperalgesia was reversed by intrathecal administration of DAMGO (a μ-opioid receptor agonist). The results suggest that chronic muscle hyperalgesia in CPCP rats did not result from an inflammatory mechanism, and there is only a low probability that it’s caused by a neuropathic mechanism.
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DOI：
10.1016/j.amjmed.2009.09.006
发表时间：
2009-12-01
期刊：
The American journal of medicine
影响因子：
--
作者：
Clauw, Daniel J
通讯作者：
Clauw, Daniel J
影响因子：
4.7
作者：
Gaida, W;Klinder, K;Weiser, T
通讯作者：
Weiser, T
影响因子：
4.7
作者：
GALER, BS;BUTLER, S;JENSEN, MP
通讯作者：
JENSEN, MP
影响因子：
7.4
作者：
Field, MJ;Bramwell, S;Singh, L
通讯作者：
Singh, L
影响因子：
7.4
作者：
Allen, G;Galer, BS;Schwartz, L
通讯作者：
Schwartz, L