Stimulation of Cryptococcus neoformans isolated from skin lesion of AIDS patient matures dendritic cells and promotes HIV-1 trans-infection.
Stimulation of Cryptococcus neoformans isolated from skin lesion of AIDS patient matures dendritic cells and promotes HIV-1 trans-infection.
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刺激从艾滋病患者皮肤病变中分离出的新型隐球菌使树突状细胞成熟并促进HIV-1转染。
DOI：
10.1016/j.bbrc.2012.06.020
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发表时间：
2012-07
影响因子：
3.1
通讯作者：
Jian-Hua Wang
中科院分区：
文献类型：
--
作者：
Yu-Ye Li;Ai-Ping Jiang;Jin-Feng Jiang;Jian-Hua Wang
树突状细胞（Dendritic cells，DC）在宿主防御真菌等入侵病原体的过程中发挥着重要作用，而真菌则以DC为靶点，对宿主的免疫应答进行有害的调节。一些研究报道了这些免疫功能低下的艾滋病患者的DC功能的真菌调制。新生隐球菌（C. neoformans）被认为是AIDS的机会性真菌之一。在这里，我们分离出了原生C。从艾滋病患者的新生儿，并研究其对DC激活和功能的影响。刺激C. neoformans使DC成熟，增强DC介导的HIV-1感染;新生儿刺激的DC促进了静息T细胞的活化，并为HIV-1感染提供了更敏感的靶点。微生物移位已被认为是慢性HIV-1感染中全身免疫激活的原因。了解病原体对HIV-1-DC相互作用的潜在影响有助于阐明病毒的发病机制，并为防止HIV的传播提供新的见解。
Dendritic cells (DCs) play a pivotal role in host defense against invaded pathogens including fungi, while DCs are targeted by fungi for deleterious regulation of the host immune response. A few studies have reported fungal modulation of DC function in these immunocompromised AIDS patients. Cryptococcus neoformans (C. neoformans) is referred as one of the opportunistic fungi of AIDS. Here, we isolated native C. neoformans from an AIDS patient and investigated its effects on DC activation and function. Stimulation of C. neoformans matured DCs, and enhanced DC-mediated HIV-1 trans-infection; moreover, C. neoformans-stimulated DCs promoted the activation of resting T cells and provided more susceptible targets for HIV-1 infection. Microbial translocation has been proposed as the cause of systemic immune activation in chronic HIV-1 infection. Understanding the potential effects of pathogens on HIV-1-DC interactions could help elucidate viral pathogenesis and provide a new insight for against the spread of HIV.
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影响因子：
11.8
作者：
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通讯作者：
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