What makes Cryptococcus neoformans a pathogen?

What makes Cryptococcus neoformans a pathogen?
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DOI:
10.3201/eid0401.980109
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发表时间:
1998-01
影响因子:
11.8
通讯作者:
Murphy JW
Murphy JW
中科院分区:
医学2区
文献类型:
--
作者:
Buchanan KL;Murphy JW

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由于艾滋病的发病和免疫抑制药物的广泛使用,由包囊真菌病原体新型隐球菌引起的危及生命的感染在过去10年中稳步增加。复杂的宿主-生物相互作用使人们对梭菌的致病性和毒力有了充分的认识。新人类很难我们讨论了目前的知识的特点C。新生儿必须具备以下条件才能进入宿主并建立进行性疾病:基本生长要求和毒力因子,如多糖荚膜;生物体脱落产物;黑色素产生;甘露醇分泌;超氧化物歧化酶;蛋白酶;和磷脂酶。
Life-threatening infections caused by the encapsulated fungal pathogen Cryptococcus neoformans have been increasing steadily over the past 10 years because of the onset of AIDS and the expanded use of immunosuppressive drugs. Intricate host-organism interactions make the full understanding of pathogenicity and virulence of C. neoformans difficult. We discuss the current knowledge of the characteristics C. neoformans must possess to enter the host and establish progressive disease: basic growth requirements and virulence factors, such as the polysaccharide capsule; shed products of the organism; melanin production; mannitol secretion; superoxide dismutase; proteases; and phospholipases.
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发表时间: 1997-02-01
影响因子: 6.4
作者:
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发表时间: 1987-01-01
影响因子: 3.1
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