Neuroimmunology of cancer and associated symptomology.
Neuroimmunology of cancer and associated symptomology.
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DOI：
10.1111/imcb.12496
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发表时间：
2021-10
影响因子：
4
通讯作者：
Saloman, Jami L.
中科院分区：
文献类型：
--
作者：
Scheff, Nicole N.;Saloman, Jami L.
从进化的角度来看，神经系统和免疫细胞已经进化到相互沟通，以控制炎症和宿主对损伤的反应。神经免疫通讯的最新发现表明，这些机制延伸到癌症的发生和发展。淋巴样结构和肿瘤常伴有炎症浸润，受多种神经类型（如交感神经、副交感神经、感觉神经）的高度支配。最近的临床前和临床研究表明，靶向神经系统可能是一种促进抗肿瘤免疫的治疗策略，同时减少癌症相关的神经系统症状，如慢性疼痛、疲劳和认知障碍。交感神经活动与生理或心理应激有关，可由肿瘤发展和癌症诊断引起。通过抑制交感神经活动或激活副交感神经活动靶向应激反应已被证明可驱动肿瘤内效应T细胞的激活和髓源性抑制细胞的抑制。此外，越来越多的证据表明，感觉神经可能通过促进或抑制肿瘤类型特异性的免疫抑制来调节肿瘤的生长和转移。由于神经效应通常是肿瘤类型特异性的，因此需要进一步研究以优化临床治疗策略。本文综述了神经免疫通讯可以调节抗肿瘤免疫以及促进癌症相关神经系统症状发展的新证据。
Evolutionarily, the nervous system and immune cells have evolved to communicate with each other to control inflammation and host responses against injury. Recent findings in neuroimmune communication demonstrate that these mechanisms extend to cancer initiation and progression. Lymphoid structures and tumors, which are often associated with inflammatory infiltrate, are highly innervated by multiple nerve types (e.g. sympathetic, parasympathetic, sensory). Recent preclinical and clinical studies demonstrate that targeting the nervous system could be a therapeutic strategy to promote antitumor immunity while simultaneously reducing cancer-associated neurological symptoms, such as chronic pain, fatigue and cognitive impairment. Sympathetic nerve activity is associated with physiological or psychological stress, which can be induced by tumor development and cancer diagnosis. Targeting the stress response through suppression of sympathetic activity or activation of parasympathetic activity has been shown to drive activation of effector T cells and inhibition of myeloid-derived suppressor cells within the tumor. In addition, there is emerging evidence that sensory nerves may regulate tumor growth and metastasis by promoting or inhibiting immunosuppression in a tumor-type specific manner. Because neural effects are often tumor-type specific, further study is required to optimize clinical therapeutic strategies. This review examines the emerging evidence that neuroimmune communication can regulate antitumor immunity as well as contribute to development of cancer-related neurological symptoms.
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影响因子：
4.6
作者：
Appel CK;Gallego-Pedersen S;Andersen L;Blancheflor Kristensen S;Ding M;Falk S;Sayilekshmy M;Gabel-Jensen C;Heegaard AM
通讯作者：
Heegaard AM
影响因子：
4.8
作者：
Andriessen AS;Donnelly CR;Ji RR
通讯作者：
Ji RR
影响因子：
4.7
作者：
Alimujiang, Aliya;Khoja, Lilah;Pearce, Celeste Leigh
通讯作者：
Pearce, Celeste Leigh
影响因子：
2.1
作者：
Chuang, YC;Yang, LC;Yoshimura, N
通讯作者：
Yoshimura, N
DOI：
10.1080/13803390903032537
发表时间：
2010-01-01
影响因子：
2.2
作者：
Cimprich, Bernadine;Reuter-Lorenz, Patricia;Welsh, Robert C.
通讯作者：
Welsh, Robert C.