Non-coordination planer cis-and trans-configuration of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)]: separation, characterization, and anticancer activity
Non-coordination planer cis-and trans-configuration of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)]: separation, characterization, and anticancer activity
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顺式-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)]的非配位平面顺式和反式构型：分离、表征和抗癌活性
DOI：
10.1007/s11164-018-3503-0
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发表时间：
2018-06
影响因子：
3.3
通讯作者：
Weiping Liu
中科院分区：
文献类型：
--
作者：
Jing Jiang;Jie Qiu;Liguang Lou;Anli Gao;Shuqian Hou;Weiping Liu
分离了cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1，1-dicarboxylate)]的两个异构体(R- = 环戊基、环己基)，并对其进行了结构表征和抗癌活性测试。X-射线结构分析表明，该异构体来源于环丁烷环上羟基相对于配位NH3的两个相反的空间取向，导致顺式和反式构型。这两个异构体具有大致相同的抗癌活性，可能是由于羟基和铂(II)配位平面之间的距离较长。因此，在药物开发过程中不建议分离这种异构体。
Two isomers of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)] (R = cycopentyl, cyclohexyl) were separated, structurally characterized and tested for their anticancer activity. X-ray structural analysis revealed that this isomerism originates from two opposite spatial orientations of the hydroxyl group on the cyclobutane ring in relation to the coordinated NH3, resulting in cis- and trans-configurations. The two isomers have approximately equal anticancer activity, probably due to a relatively long distance between the hydroxyl group and the Pt(II) coordination plane. Therefore, the separation of such isomers is not recommended during drug development.
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影响因子：
4
作者：
Wheate, Nial J.;Walker, Shonagh;Oun, Rabbab
通讯作者：
Oun, Rabbab
DOI：
10.1016/j.saa.2018.03.074
发表时间：
2018-06
期刊：
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
影响因子：
--
作者：
W. H. El-Shwiniy;W. Zordok
通讯作者：
W. H. El-Shwiniy;W. Zordok
影响因子：
5.8
作者：
Sun-Hwa Lee;K. Suk
通讯作者：
Sun-Hwa Lee;K. Suk
影响因子：
2.3
作者：
Barnard, Christopher
通讯作者：
Barnard, Christopher
影响因子：
62.1
作者：
Johnstone TC;Suntharalingam K;Lippard SJ
通讯作者：
Lippard SJ