CD1-mediated gamma/delta T cell maturation of dendritic cells.
CD1-mediated gamma/delta T cell maturation of dendritic cells.
复制标题
DOI：
10.1084/jem.20021515
复制
发表时间：
2002-12-16
影响因子：
15.3
通讯作者：
Brenner, MB
中科院分区：
文献类型：
--
作者：
Leslie, DS;Vincent, MS;Spada, FM;Das, H;Sugita, M;Morita, CT;Brenner, MB
关键词：
未成熟的髓样树突状细胞（DC）仅表达低水平的主要组织相容性复合物（MHC）II类，但在细胞表面表达高水平的CD 1 a、B和c抗原呈递分子。由于Vδ1+ γ/δ T细胞是γ/δ T细胞的主要组织亚群，并且已知它们在缺乏特异性外源抗原识别的情况下识别CD 1c，因此我们检查了这些T细胞与未成熟DC的可能相互作用。我们发现CD 1限制性γ/δ T细胞可以介导DC的成熟。DC成熟需要细胞-细胞接触，并且可以被针对CD 1c的抗体阻断。成熟过程部分由肿瘤坏死因子α介导。重要的是，未成熟的DC在脂多糖存在下成熟，CD 1限制性γ/δ T细胞产生生物活性白细胞介素-12p70。此外，这些DC能够有效地将肽抗原呈递给初始CD 4 + T细胞。未成熟DC的CD 1限制性γ/δ T细胞识别为人类免疫系统提供了在微生物入侵期间早期快速产生成熟DC库的能力。这可能是抗原特异性幼稚T细胞的T辅助细胞1型极化和随后的适应性免疫应答的关键宿主信号的重要来源。
Immature myeloid dendritic cells (DCs) express only low levels of major histocompatibility complex (MHC) class II but express high levels of CD1 a, b, and c antigen-presenting molecules at the cell surface. As Vδ1+ γ/δ T cells are the main tissue subset of γ/δ T cells and they are known to recognize CD1c in the absence of specific foreign antigen recognition, we examined the possible interaction of these T cells with immature DCs. We show that CD1-restricted γ/δ T cells can mediate the maturation of DCs. DC maturation required cell–cell contact and could be blocked by antibodies against CD1c. The maturation process was partially mediated by tumor necrosis factor α. Importantly, immature DCs matured in the presence of lipopolysaccharide and CD1-restricted γ/δ T cells produced bioactive interleukin-12p70. In addition, these DCs were able to efficiently present peptide antigens to naive CD4+ T cells. CD1-restricted γ/δ T cell recognition of immature DCs provides the human immune system with the capacity to rapidly generate a pool of mature DCs early during microbial invasion. This may be an important source of critical host signals for T helper type 1 polarization of antigen-specific naive T cells and the subsequent adaptive immune response.
登录
查看更多内容
影响因子：
64.8
作者：
PORCELLI, S;MORITA, CT;BRENNER, MB
通讯作者：
BRENNER, MB
影响因子：
4.4
作者：
Sallusto, Federica;Lanzavecchia, Antonio
通讯作者：
Lanzavecchia, Antonio
影响因子：
20.3
作者：
Hilkens, CMU;Kalinski, P;Kapsenberg, ML
通讯作者：
Kapsenberg, ML
影响因子：
3.1
作者：
Hviid, L;Kurtzhals, JAL;Behr, C
通讯作者：
Behr, C
影响因子：
2.9
作者：
MORIKAWA, S;INUBUSHI, T;AMANO, S
通讯作者：
AMANO, S