Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity.
Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity.
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DOI：
10.1111/j.1365-2222.2010.03559.x
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Cooper PJ
中科院分区：
文献类型：
--
作者：
Endara P;Vaca M;Chico ME;Erazo S;Oviedo G;Quinzo I;Rodriguez A;Lovato R;Moncayo AL;Barreto ML;Rodrigues LC;Cooper PJ
热带农村地区过敏性疾病的低发病率归因于慢性蠕虫感染的保护作用。令人关切的是，对这些寄生虫采取以治疗为基础的控制方案可能会导致过敏性疾病的流行率上升。我们测量了15-17年伊维菌素驱虫治疗对学龄儿童过敏原皮试反应性和过敏症状患病率的影响。比较了居住在接受伊维菌素社区治疗（用于盘尾丝虫病控制）15-17年的社区的学龄儿童与居住在地理相邻社区未接受伊维菌素治疗的学龄儿童之间过敏原皮试反应性、运动诱发的支气管痉挛和过敏症状的患病率。与未接受治疗的社区相比，生活在接受治疗的社区的儿童过敏原皮试反应性的患病率是未接受治疗的社区的儿童的两倍（16.7% vs. 8.7%，校正OR 2.10，95%CI 1.50-2.94，P<0.0001），并且该效应部分由接受治疗的儿童中鞭虫患病率降低介导。伊维菌素治疗与近期湿疹症状的患病率增加相关（校正OR 2.24，95%CI 1.05-4.78，P=0.04），但与哮喘或鼻结膜炎症状无关。对湿疹症状的影响与土蠕虫感染的减少无关。伊维菌素长期定期治疗与过敏原皮试反应性患病率增加相关。有证据表明，治疗与近期湿疹症状的患病率增加有关，但与哮喘或鼻结膜炎的患病率无关。Cite this as：P. Endara，M. Vaca，M. E.奇科，S.埃拉索湾奥维耶多岛Quinzo，A.罗德里格斯河洛瓦托，A.- L.蒙卡约湾L.巴雷托湖C. Rodrigues和P. J.库珀，临床和实验过敏，2010（40）1669-1677。
The low prevalence of allergic disease in the rural tropics has been attributed to the protective effects of chronic helminth infections. There is concern that treatment-based control programmes for these parasites may lead to an increase in the prevalence of allergic diseases. We measured the impact of 15–17 years of anthelmintic treatment with ivermectin on the prevalence of allergen skin test reactivity and allergic symptoms in school-age children. The prevalence of allergen skin test reactivity, exercise-induced bronchospasm and allergic symptoms was compared between school-age children living in communities that had received community-based treatments with ivermectin (for onchocerciasis control) for a period of 15–17 years with those living in geographically adjacent communities that had received no ivermectin. The prevalence of allergen skin test reactivity was double in children living in treated communities compared with those in untreated communities (16.7% vs. 8.7%, adjusted OR 2.10, 95% CI 1.50–2.94, P<0.0001), and the effect was mediated partly by a reduced prevalence of Trichuris trichiura among treated children. Ivermectin treatments were associated with an increased prevalence of recent eczema symptoms (adjusted OR 2.24, 95% CI 1.05–4.78, P=0.04) but not symptoms of asthma or rhino-conjunctivitis. The effect on eczema symptoms was not associated with reductions in geohelminth infections. Long-term periodic treatments with ivermectin were associated with an increased prevalence of allergen skin test reactivity. There was some evidence that treatment was associated with an increased prevalence of recent eczema symptoms but not those of asthma or rhino-conjunctivitis. Cite this as: P. Endara, M. Vaca, M. E. Chico, S. Erazo, G. Oviedo, I. Quinzo, A. Rodriguez R. Lovato, A.-L. Moncayo, M. L. Barreto, L. C. Rodrigues and P. J. Cooper, Clinical & Experimental Allergy, 2010 (40) 1669–1677.
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影响因子：
2.8
作者：
GUDERIAN, RH;SHELLEY, AJ
通讯作者：
SHELLEY, AJ
影响因子：
168.9
作者：
Scrivener, S;Yemaneberhan, H;Britton, J
通讯作者：
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影响因子：
6.7
作者：
Cooper, P. J.;Barreto, M. L.;Rodrigues, L. C.
通讯作者：
Rodrigues, L. C.
影响因子：
14.2
作者：
LYNCH, NR;HAGEL, I;ALVAREZ, N
通讯作者：
ALVAREZ, N
影响因子：
5.9
作者：
Ponte, EV;Lima, F;Cruz, AA
通讯作者：
Cruz, AA