Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia.
Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia.
复制标题
DOI：
10.1016/j.schres.2008.12.025
复制
发表时间：
2009-03
影响因子：
4.5
通讯作者：
Cannon, Tyrone D.
中科院分区：
文献类型：
--
作者：
Karlsgodt, Katherine H.;Sanz, Jacqueline;van Erp, Theo G. M.;Bearden, Carrie E.;Nuechterlein, Keith H.;Cannon, Tyrone D.
关键词：
先前对精神分裂症工作记忆（WM）的神经影像学研究得出了额额不足和额额过多的相互矛盾的发现，这些差异可能是由任务难度和/或表现的差异引起的。本研究通过将负荷变化与整体个体表现差异相结合，提出并测试了精神分裂症表现-激活关系的新模型。 14 名新发精神分裂症患者和 18 名对照者在执行参数化言语 WM 任务时接受了功能性磁共振成像。群体水平差异遵循线性“交叉”模式，因此在对照组中，背外侧前额叶皮层（DLPFC）的激活随着表现的下降而增加，而患者则表现出相反的情况。总体而言，与对照组相比，低表现患者活动不足，而高表现患者则过度活跃。然而，患者和对照组表现出类似的负载激活功能，其中激活随着任务难度而上升，但在较高负载下趋于平稳或略有下降。此外，在所有负荷和他们自己的 WM 能力下，表现较高的患者表现出比对照组更强的 DLPFC 激活，而表现较低的患者激活最少。这项研究建立了一个新的框架，通过将每个受试者体内发生的 WM 负载引起的激活变化与与一般 WM 表现相关的激活的总体差异相结合，来预测功能激活和 WM 表现之间的关系。从本质上讲，任务难度的增加与所有受试者的激活程度的增加渐近相关，但根据他们的行为表现，患者表现出整体的高额性与低额性，这种模式可能源于潜在细胞变化的个体差异，这些变化可能与功能障碍的水平有关。
Previous neuroimaging studies of working memory (WM) in schizophrenia have generated conflicting findings of hypo- and hyper-frontality, discrepancies potentially driven by differences in task difficulty and/or performance. This study proposes and tests a new model of the performance-activation relationship in schizophrenia by combining changes by load with overall individual differences in performance. Fourteen patients with recent-onset schizophrenia and eighteen controls underwent functional magnetic resonance imaging while performing a parametric verbal WM task. Group level differences followed a linear “cross-over” pattern, such that in controls, activation in the dorsolateral prefrontal cortex (DLPFC) increased as performance decreased, while patients showed the opposite. Overall, low performing patients were hypoactive and high performing patients hyperactive relative to controls. However, patients and controls showed similar functions of activation by load in which activation rises with task difficulty but levels off or slightly decreases at higher loads. Moreover, across all loads and at their own WM capacity, higher performing patients showed greater DLPFC activation than controls, while lower performing patients activated least. This study establishes a novel framework for predicting the relationship between functional activation and WM performance by combining changes of activation by WM load occurring within each subject with the overall differences in activation associated with general WM performance. Essentially, increasing task difficulty correlates asymptotically with increasing activation in all subjects, but depending on their behavioral performance, patients show overall hyper-versus hypofrontality, a pattern potentially derived from individual differences in underlying cellular changes that may relate to levels of functional disability.
登录
查看更多内容
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
2.5
作者：
FUSTER, JM
通讯作者：
FUSTER, JM
影响因子：
56.9
作者：
STERNBERG, S
通讯作者：
STERNBERG, S
影响因子：
25
作者：
Rypma, B;D'Esposito, M
通讯作者：
D'Esposito, M
影响因子：
17.7
作者：
Callicott, JH;Mattay, VS;Weinberger, DR
通讯作者：
Weinberger, DR