Chimpanzee malaria parasites related to Plasmodium ovale in Africa.
Chimpanzee malaria parasites related to Plasmodium ovale in Africa.
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DOI：
10.1371/journal.pone.0005520
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Ariey F
中科院分区：
文献类型：
--
作者：
Duval L;Nerrienet E;Rousset D;Sadeuh Mba SA;Houze S;Fourment M;Le Bras J;Robert V;Ariey F
自20世纪70年代S以来，非洲大猩猩体内疟原虫的多样性一直被忽视。令人惊讶的是，黑猩猩寄生虫P.reichenowi是唯一一种已经被分子表征的寄生虫。这种寄生虫与恶性疟原虫有密切的亲缘关系，恶性疟原虫是人类疟疾负担最大的主要原因。对类人型灵长类动物疟疾寄生虫的研究可能提供相关的系统发育信息，提高我们对人类疟疾物种起源和进化史的理解。在这项研究中，我们使用细胞色素b分子工具，对来自喀麦隆的130个黑猩猩和大猩猩(大猩猩)的DNA样本进行了疟原虫感染的筛选。来自黑猩猩亚种的两只黑猩猩只感染了与人类疟疾寄生虫卵形疟原虫分子上相关的疟原虫菌株。用细胞色素b和细胞色素c氧化酶1、线粒体部分基因和核乳酸脱氢酶部分基因对这些黑猩猩寄生虫和来自非洲和亚洲不同地点的13株人卵圆假单胞菌进行了鉴定。与之前的发现一致的是，在不同地理位置的人群中观察到了两种不同的遗传类型的卵圆假单胞菌，经典的和变异的。一种黑猩猩疟原虫品系在所有三个标记上与变异的卵形疟原虫类型在遗传上相同。另一株黑猩猩疟原虫与分离自人的卵形疟原虫不同。这项研究首次证明了人与黑猩猩之间可能存在卵圆假单胞菌的自然跨种交换。
Since the 1970's, the diversity of Plasmodium parasites in African great apes has been neglected. Surprisingly, P. reichenowi, a chimpanzee parasite, is the only such parasite to have been molecularly characterized. This parasite is closely phylogenetically related to P. falciparum, the principal cause of the greatest malaria burden in humans. Studies of malaria parasites from anthropoid primates may provide relevant phylogenetic information, improving our understanding of the origin and evolutionary history of human malaria species. In this study, we screened 130 DNA samples from chimpanzees (Pan troglodytes) and gorillas (Gorilla gorilla) from Cameroon for Plasmodium infection, using cytochrome b molecular tools. Two chimpanzees from the subspecies Pan t. troglodytes presented single infections with Plasmodium strains molecularly related to the human malaria parasite P. ovale. These chimpanzee parasites and 13 human strains of P. ovale originated from a various sites in Africa and Asia were characterized using cytochrome b and cytochrome c oxidase 1 mitochondrial partial genes and nuclear ldh partial gene. Consistent with previous findings, two genetically distinct types of P. ovale, classical and variant, were observed in the human population from a variety of geographical locations. One chimpanzee Plasmodium strain was genetically identical, on all three markers tested, to variant P. ovale type. The other chimpanzee Plasmodium strain was different from P. ovale strains isolated from humans. This study provides the first evidence of possibility of natural cross-species exchange of P. ovale between humans and chimpanzees of the subspecies Pan t. troglodytes.
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影响因子：
5.8
作者：
Posada, D;Crandall, KA
通讯作者：
Crandall, KA
影响因子：
3
作者：
Duval, Linda;Robert, Vincent;Ariey, Frederic
通讯作者：
Ariey, Frederic
影响因子：
2
作者：
Hagner, S. C.;Misof, B.;Kampen, H.
通讯作者：
Kampen, H.
DOI：
10.4269/ajtmh.1970.19.190
发表时间：
1970-01-01
影响因子：
3.3
作者：
CONTACOS, PG;COATNEY, GR;JETER, MH
通讯作者：
JETER, MH
DOI：
10.4269/ajtmh.1997.56.440
发表时间：
1997-04-01
影响因子：
3.3
作者：
Ollomo, B;Karch, S;Millet, P
通讯作者：
Millet, P