Association between fibroblast growth factor 7 and the risk of chronic obstructive pulmonary disease
Association between fibroblast growth factor 7 and the risk of chronic obstructive pulmonary disease
复制标题
成纤维细胞生长因子 7 与慢性阻塞性肺疾病风险之间的关联
DOI：
10.1038/aps.2012.69
复制
发表时间：
2012-07
影响因子：
8.2
通讯作者：
Su, Zhi-guang
中科院分区：
文献类型：
--
作者：
Xu, Si-cheng;Kuang, Jiang-ying;Liu, Jin;Ma, Chun-lan;Feng, Yu-lin;Su, Zhi-guang
Aim:Fibroblast growth factor 7 (FGF7) is involved in a number of physiological and pathological processes, including lung disease. However, relatively little is known about the effect of FGF7 gene polymorphisms on chronic obstructive pulmonary disease (COPD) susceptibility. This study aimed to investigate the association between FGF7 polymorphisms with COPD susceptibility in a Chinese Han population.Methods:We conducted a case-control study of 279 COPD patients and 367 age-and gender-distribution-matched control subjects. The tagging SNPs rs10519225 and rs7170426 in FGF7 were genotyped by SNaPshot. The associations of each SNP genotype and haplotype constructed by these loci with COPD were analyzed.Results:A multivariate analysis showed that rs10519225 was significantly associated with an increased risk of COPD (P= 0.011, OR= 1.535, FDR q= 0.022), whereas no association was found for rs7170426. Linkage disequilibrium (LD) analysis showed that these loci were in weak LD, with an r 2 of 0.033 and a D′ of 0.232 (95% CI: 0.150–0.520). The haplotype constructed by allele G at rs10519225 and allele A at rs7170426 was associated with a decreased susceptibility to COPD (P= 0.012, OR= 0.751, FDR q= 0.048).Conclusion:These findings suggest that FGF7 may be one susceptibility factor for COPD.IntroductionChronic obstructive pulmonary disease (COPD) is currently the leading cause of decreases in disability-adjusted life years (DALY). Globally, it is projected to be the third most important cause of DALY by the year 2020 1, and it is estimated that COPD affects nearly 8.2% of the Chinese adult population 2. Cigarette smoking is the major environmental risk factor for COPD; however, only approximately 15% of smokers develop clinically relevant airflow obstruction 3. The variation in the susceptibility to cigarette smoke, in combination with the familial inheritance pattern of COPD, suggests that there may be a genetic component to the development of COPD 4. Multiple studies in diverse populations have demonstrated the genetic contribution to the variability in pulmonary function and the familial aggregation of COPD. As expected, segregation analysis suggests that multiple genes may be involved in COPD susceptibility. The associations between COPD and polymorphisms in genes with potential importance in COPD pathogenesis have been investigated 5; however, only α1-antitrypsin has been unequivocally identified as relevant to the development of COPD. Recently, polymorphisms in the CHRNA3-CHRNA5-IREB2, HHIP, and FAM13A loci have been found to be associated with COPD by genome-wide association studies (GWAS) 6, 7, 8.
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DOI：
10.1164/ajrccm.161.1.9812131
发表时间：
2000
影响因子：
24.7
作者：
N. Seersholm;J. Wilcke;A. Kok-Jensen;A. Dirksen
通讯作者：
N. Seersholm;J. Wilcke;A. Kok-Jensen;A. Dirksen
DOI：
10.1097/00001503-199112000-00019
发表时间：
1991-12
期刊：
Current Opinion in Anaesthesiology
影响因子：
--
作者：
P. Roe;J. Jones
通讯作者：
P. Roe;J. Jones
DOI：
10.1164/ajrccm/140.3_pt_2.s82
发表时间：
1989-09-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
DAVIS, RM;NOVOTNY, TE
通讯作者：
NOVOTNY, TE
影响因子：
10
作者：
Brehm JM;Hagiwara K;Tesfaigzi Y;Bruse S;Mariani TJ;Bhattacharya S;Boutaoui N;Ziniti JP;Soto-Quiros ME;Avila L;Cho MH;Himes B;Litonjua AA;Jacobson F;Bakke P;Gulsvik A;Anderson WH;Lomas DA;Forno E;Datta S;Silverman EK;Celedón JC
通讯作者：
Celedón JC
影响因子：
56.9
作者：
Murray, CJL;Lopez, AD
通讯作者：
Lopez, AD