New Insights into Adipose Tissue Macrophages in Obesity and Insulin Resistance.
New Insights into Adipose Tissue Macrophages in Obesity and Insulin Resistance.
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对肥胖和胰岛素抵抗中脂肪组织巨噬细胞的新见解。
作者：
肥胖已成为一种世界性的流行病，严重威胁着人类的健康。有证据表明，许多肥胖合并症，例如2型糖尿病、脂肪性肝炎和心血管疾病，都与肥胖引起的慢性低度炎症有关。巨噬细胞是参与小鼠和人类肥胖相关炎症的主要免疫细胞。过去几年的深入研究使我们对脂肪组织巨噬细胞（ATM）在肥胖和相关合并症中除了经典的M1/M2极化之外的其他作用的理解取得了巨大进展。在这篇综述中，我们首先描述了肥胖背景下ATM的不同亚群。此外，我们还综述了脂肪细胞和ATM之间广泛的串扰在肥胖中的作用的最新进展。最后，我们专注于血管周围间充质细胞和ATM之间的脂肪组织内的扩展串扰。了解肥胖症的病理机制对于开发新的干预策略来预防或治疗这种疾病及其相关的合并症至关重要。
Obesity has become a worldwide epidemic that poses a severe threat to human health. Evidence suggests that many obesity comorbidities, such as type 2 diabetes mellitus, steatohepatitis, and cardiovascular diseases, are related to obesity-induced chronic low-grade inflammation. Macrophages are the primary immune cells involved in obesity-associated inflammation in both mice and humans. Intensive research over the past few years has yielded tremendous progress in our understanding of the additional roles of adipose tissue macrophages (ATMs) beyond classical M1/M2 polarization in obesity and related comorbidities. In this review, we first characterize the diverse subpopulations of ATMs in the context of obesity. Furthermore, we review the recent advance on the role of the extensive crosstalk between adipocytes and ATMs in obesity. Finally, we focus on the extended crosstalk within adipose tissue between perivascular mesenchymal cells and ATMs. Understanding the pathological mechanisms that underlie obesity will be critical for the development of new intervention strategies to prevent or treat this disease and its associated co-morbidities.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
5.2
作者：
Choe SS;Huh JY;Hwang IJ;Kim JI;Kim JB
通讯作者：
Kim JB
影响因子：
56.9
作者：
Cox, Nehemiah;Crozet, Lucile;Holtman, Inge R.;Loyher, Pierre-Louis;Lazarov, Tomi;White, Jessica B.;Mass, Elvira;Stanley, E. Richard;Elemento, Olivier;Glass, Christopher K.;Geissmann, Frederic
通讯作者：
Geissmann, Frederic
细胞间线粒体向巨噬细胞转移可调节白色脂肪组织稳态，并在肥胖症中受损。
影响因子：
29
作者：
Brestoff JR;Wilen CB;Moley JR;Li Y;Zou W;Malvin NP;Rowen MN;Saunders BT;Ma H;Mack MR;Hykes BL Jr;Balce DR;Orvedahl A;Williams JW;Rohatgi N;Wang X;McAllaster MR;Handley SA;Kim BS;Doench JG;Zinselmeyer BH;Diamond MS;Virgin HW;Gelman AE;Teitelbaum SL
通讯作者：
Teitelbaum SL
影响因子：
30.5
作者：
Hildreth AD;Ma F;Wong YY;Sun R;Pellegrini M;O'Sullivan TE
通讯作者：
O'Sullivan TE