Childhood malnutrition and the intestinal microbiome.
Childhood malnutrition and the intestinal microbiome.
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DOI：
10.1038/pr.2014.179
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发表时间：
2015-01
影响因子：
3.6
通讯作者：
Ward, Honorine D.
中科院分区：
文献类型：
--
作者：
Kane, Anne V.;Dinh, Duy M.;Ward, Honorine D.
在所有5岁以下儿童死亡中，营养不良几乎占一半，特别是那些生活在资源有限地区的儿童。那些存活下来的人经常遭受长期的后遗症，包括生长衰竭和神经发育障碍。营养不良是免疫力受损、反复感染和营养不良恶化恶性循环的一部分。最近，肠道微生物组的改变也与儿童营养不良密切相关。有研究表明，营养不良可能会延迟儿童早期肠道微生物群的正常发育，或迫使其组成发生改变，从而缺乏健康生长所需的功能和/或增加肠道炎症的风险。这篇综述阐述了我们目前对肠道微生物群对人类营养的有益贡献（以及肠道微生物群变化对营养不良的潜在作用）、获得肠道微生物群的过程、营养不良对微生物群发育的潜在影响以及肠道微生物群改变与儿童营养不良直接相关的证据的理解。我们回顾了最近关于肠道微生物群改变与儿童早期营养不良之间关系的研究，并在干预或预防营养不良造成的破坏的背景下讨论了这些研究。
Malnutrition contributes to almost half of all deaths in children under the age of 5 years, particularly those who live in resource-constrained areas. Those who survive frequently suffer from long-term sequelae including growth failure and neurodevelopmental impairment. Malnutrition is part of a vicious cycle of impaired immunity, recurrent infections and worsening malnutrition. Recently, alterations in the gut microbiome have also been strongly implicated in childhood malnutrition. It has been suggested that malnutrition may delay the normal development of the gut microbiota in early childhood or force it towards an altered composition that lacks the required functions for healthy growth and/or increases the risk for intestinal inflammation. This review addresses our current understanding of the beneficial contributions of gut microbiota to human nutrition (and conversely the potential role of changes in that community to malnutrition), the process of acquiring an intestinal microbiome, potential influences of malnutrition on the developing microbiota and the evidence directly linking alterations in the intestinal microbiome to childhood malnutrition. We review recent studies on the association between alterations in the intestinal microbiome and early childhood malnutrition and discuss them in the context of implications for intervention or prevention of the devastation caused by malnutrition.
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影响因子：
64.8
作者：
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