The treatment-naive microbiome in new-onset Crohn's disease.
The treatment-naive microbiome in new-onset Crohn's disease.
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DOI：
10.1016/j.chom.2014.02.005
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发表时间：
2014-03-12
影响因子：
30.3
通讯作者：
Xavier RJ
中科院分区：
文献类型：
--
作者：
Gevers D;Kugathasan S;Denson LA;Vázquez-Baeza Y;Van Treuren W;Ren B;Schwager E;Knights D;Song SJ;Yassour M;Morgan XC;Kostic AD;Luo C;González A;McDonald D;Haberman Y;Walters T;Baker S;Rosh J;Stephens M;Heyman M;Markowitz J;Baldassano R;Griffiths A;Sylvester F;Mack D;Kim S;Crandall W;Hyams J;Huttenhower C;Knight R;Xavier RJ
炎症性肠病（IBD），包括克罗恩病（CD），与宿主途径遗传相关，所述宿主途径涉及对肠道微生物群的异常免疫应答的潜在作用。然而，IBD患者肠道微生物组生态失调的模式在已发表的研究中不一致。使用在新发病例治疗前收集的多个胃肠道位置的样本，我们研究了迄今为止最大的儿科CD队列中的微生物组。由包括肠杆菌科、巴斯德菌科、韦荣氏球菌科和梭杆菌科的细菌的丰度增加以及丹毒毛菌属、拟杆菌目和梭菌目的丰度减少定义的轴与疾病状态强烈相关。有和没有抗生素暴露的CD患者之间的微生物组比较表明，抗生素的使用放大了与CD相关的微生物生态失调。比较回肠、直肠和粪便样本之间的微生物特征表明，在疾病的早期阶段，评估直肠粘膜相关微生物组为方便和早期诊断CD提供了独特的潜力。
Inflammatory bowel diseases (IBD), including Crohn’s disease (CD), are genetically linked to host pathways that implicate an underlying role for aberrant immune responses to intestinal microbiota. However, patterns of gut microbiome dysbiosis in IBD patients are inconsistent among published studies. Using samples from multiple gastrointestinal locations collected prior to treatment in new-onset cases, we studied the microbiome in the largest pediatric CD cohort to date. An axis defined by an increased abundance in bacteria which include Enterobacteriaceae, Pasteurellacaea, Veillonellaceae, and Fusobacteriaceae, and decreased abundance in Erysipelotrichales, Bacteroidales, and Clostridiales, correlates strongly with disease status. Microbiome comparison between CD patients with and without antibiotic exposure indicates that antibiotic use amplifies the microbial dysbiosis associated with CD. Comparing the microbial signatures between the ileum, rectum, and fecal samples indicates that at this early stage of disease, assessing the rectal mucosa-associated microbiome offers unique potential for convenient and early diagnosis of CD.
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基于从元基因组数据重建的基因组，Rothia粘膜粘膜对CF肺部持久性的适应性模型。
影响因子：
3.7
作者：
Lim YW;Schmieder R;Haynes M;Furlan M;Matthews TD;Whiteson K;Poole SJ;Hayes CS;Low DA;Maughan H;Edwards R;Conrad D;Rohwer F
通讯作者：
Rohwer F
DOI：
10.1007/s10482-011-9616-8
发表时间：
2011-08
影响因子：
2.6
作者：
Gupta, Radhey S.
通讯作者：
Gupta, Radhey S.
影响因子：
5.7
作者：
Harrison A;Bakaletz LO;Munson RS Jr
通讯作者：
Munson RS Jr
影响因子：
7
作者：
Lozupone CA;Stombaugh J;Gonzalez A;Ackermann G;Wendel D;Vázquez-Baeza Y;Jansson JK;Gordon JI;Knight R
通讯作者：
Knight R
影响因子：
64.8
作者：
Khor, Bernard;Gardet, Agnes;Xavier, Ramnik J.
通讯作者：
Xavier, Ramnik J.