Unifocal Invasive Lobular Carcinoma: Tumor Size Concordance Between Preoperative Ultrasound Imaging and Postoperative Pathology.
Unifocal Invasive Lobular Carcinoma: Tumor Size Concordance Between Preoperative Ultrasound Imaging and Postoperative Pathology.
复制标题
DOI：
10.1016/j.clbc.2018.07.017
复制
发表时间：
2018-12
影响因子：
3.1
通讯作者：
Hultman R
中科院分区：
文献类型：
--
作者：
Vijayaraghavan GR;Vedantham S;Santos-Nunez G;Hultman R
以组织病理学为参考标准，系统分析超声对单灶性浸润性小叶癌（ILC）病变范围的判断。在这项单机构回顾性研究中，在5年期间确定了128例ILC病例。排除后，分析的队列包括66例病例。超声测量肿瘤范围沿着三个轴。肿瘤大小确定为三个轴中的最大范围，肿瘤体积通过椭球近似确定。病理学审查提供了肿瘤大小和体积。对超声和病理诊断的肿瘤大小和体积进行相关和回归分析。来自超声和病理学的肿瘤分期用于一致性分析。超声和病理诊断肿瘤大小的中位数（Q1，Q3）分别为12.5mm（9mm，19 mm）和17 mm（12 mm，25 mm）。超声和病理诊断肿瘤体积的中位数（Q1，Q3）分别为0.52cm ~ 3（0.18cm ~ 3，1.92cm ~ 3）和1.04cm ~ 3（0.45cm ~ 3，2.49cm ~ 3）。超声测量值与病理报告的肿瘤大小（斯皮尔曼ρ=0.678，p<0.0001）和体积（斯皮尔曼ρ=0.699，p<0.0001）相关。超声测量的尺寸和体积与病理学报告的尺寸和体积不同（p<0.0001，Wilcoxon符号秩检验）。超声诊断的临床肿瘤大小分期（cT）和病理肿瘤大小分期（pT）之间的一致性随pT而变化（p=0.0003，Fisher精确检验），在pT 1肿瘤中观察到的最高一致率为95.7%（95% CL：85.2%-99.5%）。超声低估了肿瘤的大小和体积，对于较大的肿瘤，低估程度增加。因此，超声和病理学之间肿瘤大小分期的一致率是肿瘤大小依赖性的，在pT 1肿瘤中观察到最高的一致率。术前超声成像可以提供肿瘤尺寸测量。在浸润性小叶癌（ILC）中，尚不清楚超声和病理学之间肿瘤大小分期（T分期）的一致性是否取决于肿瘤T分期本身。从128个ILC的队列中，分析了66个单焦点ILC。来自超声的临床肿瘤大小分期（cT）与病理肿瘤大小分期（pT）之间的一致性随pT而变化（p=0.0003，Fisher精确检验），对于pTl肿瘤观察到的最高一致率为95.7%（95%CL：85.2% - 99.5%）。使用超声对大于pT 1的ILC进行分期时应谨慎。
To systematically analyze the extent-of-disease in unifocal invasive lobular carcinoma (ILC) using ultrasound, with histopathology as the reference standard. In this single-institution retrospective study, 128 cases of ILC were identified over a 5-year period. After exclusions, the analyzed cohort consisted 66 cases. Ultrasound measurements of tumor extent along three axes were obtained. Tumor size was determined as the largest extent among the three axes and tumor volume by ellipsoidal approximation. Pathology review provided tumor size and volume. Correlation and regression analyses of tumor size and volume from ultrasound and pathology were performed. Tumor stage from ultrasound and pathology were used for concordance analyses. The median (Ql, Q3) of tumor size from ultrasound and pathology were 12.5mm (9mm, 19mm) and 17mm (12mm, 25mm), respectively. The median (Ql, Q3) of tumor volume from ultrasound and pathology were 0.52cm3 (0.18cm3, 1.92cm3) and 1.04cm3 (0.45cm3, 2.49cm3), respectively. Ultrasound measurements were correlated with pathology reported tumor size (Spearman ρ=0.678, p<0.0001) and volume (Spearman ρ=0.699, p<0.0001). Ultrasound measured size and volume differed from pathology reported size and volume (p<0.0001, Wilcoxon signed ranks test). Concordancy between clinical tumor-size stage from ultrasound (cT) and pathology tumor-size stage (pT) varied with pT (p=0.0003, Fisher’s exact test), with the highest concordancy rate of 95.7% (95% CL: 85.2%−99.5%) observed for pT 1 tumors. Ultrasound underestimates tumor size and volume with the underestimation increasing for larger tumors. Hence, the concordancy rate in tumor-size stage between ultrasound and pathology is tumor-size dependent with highest concordancy rate observed for pT 1 tumors. Pre-surgical ultrasound imaging can provide for tumor size measurements. In invasive lobular carcinoma (ILC), it is unclear if the concordancy in tumor-size stage (T-stage) between ultrasound and pathology is dependent on the tumor T-stage itself. From a cohort of 128 ILCs, 66 unifocal ILCs were analyzed. Concordancy between clinical tumor-size stage from ultrasound (cT) and pathology tumor-size stage (pT) varied with pT (p=0.0003, Fisher’s exact test), with the highest concordancy rate of 95.7% (95% CL: 85.2% - 99.5%) observed for pTl tumors. Caution is expressed for using ultrasound to stage ILCs larger than pT 1.
登录
查看更多内容
影响因子：
3.7
作者：
Truin W;Vugts G;Roumen RM;Maaskant-Braat AJ;Nieuwenhuijzen GA;van der Heiden-van der Loo M;Tjan-Heijnen VC;Voogd AC
通讯作者：
Voogd AC
影响因子：
2.6
作者：
Evans, N;Lyons, K
通讯作者：
Lyons, K
影响因子：
3.9
作者：
Dummin, L. J.;Cox, M.;Plant, L.
通讯作者：
Plant, L.
影响因子：
3.9
作者：
Jung, Hye Na;Shin, Jung Hee;Cho, Eun Yoon
通讯作者：
Cho, Eun Yoon
影响因子：
3
作者：
Onesti, Jill K.;Mangus, Barry E.;Osland, Jacqueline S.
通讯作者：
Osland, Jacqueline S.