Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years.
Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years.
复制标题
DOI：
10.1001/jamapediatrics.2018.1960
复制
发表时间：
2018-10-01
期刊：
影响因子：
26.1
通讯作者：
Reiner RC Jr
中科院分区：
文献类型：
--
作者：
Troeger C;Khalil IA;Rao PC;Cao S;Blacker BF;Ahmed T;Armah G;Bines JE;Brewer TG;Colombara DV;Kang G;Kirkpatrick BD;Kirkwood CD;Mwenda JM;Parashar UD;Petri WA Jr;Riddle MS;Steele AD;Thompson RL;Walson JL;Sanders JW;Mokdad AH;Murray CJL;Hay SI;Reiner RC Jr
对全球疾病负担研究数据的分析研究了全球5岁以下儿童轮状病毒感染的程度和相关死亡率，以及轮状病毒疫苗是否降低了轮状病毒相关死亡率。5岁以下儿童轮状病毒感染的程度如何，轮状病毒疫苗如何减轻这一全球负担？这份全球疾病负担报告以及对轮状病毒和轮状病毒疫苗接种结果的几项扩展分析发现，2016年轮状病毒感染导致128500例死亡和258173300例5岁以下儿童腹泻。据估计，轮状病毒疫苗在2016年避免了约28，000例死亡，如果当年实现了疫苗的全面覆盖，本可以再挽救约83，200名儿童。在继续减少全球轮状病毒负担方面，有必要优先采用轮状病毒疫苗和干预措施，以减少与疟疾相关的发病率和死亡率。轮状病毒感染是全球5岁以下儿童腹泻相关发病率和死亡率的主要原因。研究各国5岁以下儿童轮状病毒感染的程度以及因轮状病毒疫苗而避免的死亡人数。本报告基于2016年全球疾病负担研究的结果，该研究是一项横断面研究，测量了肠道疾病及其病原体。模型被用来估计数据稀疏的位置的负担。轮状病毒感染引起的腹泻。按国家和年份分列的轮状病毒相关死亡率和发病率以及按国家分列的轮状病毒疫苗避免的死亡。2016年，轮状病毒感染导致全球5岁以下儿童约128500例死亡（95%不确定区间[UI]，104500 - 155600），其中104733例死亡发生在撒哈拉以南非洲（95% UI，83406 - 128842）。2016年，轮状病毒感染导致5岁以下儿童腹泻超过2.58亿次（95%UI，1.93亿至3.41亿），发病率为每儿童年0.42例（95%UI，0.30-0.53）。据估计，在5岁以下儿童中，疫苗的使用避免了28000多例死亡（95% UI，14600 - 46700），扩大轮状病毒疫苗的使用，特别是在撒哈拉以南非洲，可以预防约20%的5岁以下儿童腹泻死亡。随着时间的推移，轮状病毒相关死亡率显著下降，部分原因是轮状病毒疫苗的引入。这项研究表明，在全球轮状病毒感染的持续减少中，优先考虑疫苗的引入和干预措施，以减少与疟疾相关的发病率和死亡率是必要的。
This analysis of data from the Global Burden of Disease Study examines the extent of rotavirus infection and associated deaths among children younger than 5 years worldwide and whether the rotavirus vaccine has reduced the diarrhea-associated mortality. What is the extent of rotavirus infection among children younger than 5 years, and how has the rotavirus vaccine reduced this global burden? This report of the Global Burden of Disease and several extended analyses on rotavirus and results of rotavirus vaccination found that rotavirus infection caused 128 500 deaths and 258 173 300 episodes of diarrhea among children younger than 5 years in 2016. The rotavirus vaccine is estimated to have averted approximately 28 000 deaths in 2016, and approximately 83 200 additional children could have been saved had full vaccine coverage been achieved that year. Prioritizing the introduction of the rotavirus vaccine and interventions to reduce diarrhea-associated morbidity and mortality are necessary in the continued reduction of the global rotavirus burden. Rotavirus infection is the global leading cause of diarrhea-associated morbidity and mortality among children younger than 5 years. To examine the extent of rotavirus infection among children younger than 5 years by country and the number of deaths averted because of the rotavirus vaccine. This report builds on findings from the Global Burden of Disease Study 2016, a cross-sectional study that measured diarrheal diseases and their etiologic agents. Models were used to estimate burden in data-sparse locations. Diarrhea due to rotavirus infection. Rotavirus-associated mortality and morbidity by country and year and averted deaths attributable to the rotavirus vaccine by country. Rotavirus infection was responsible for an estimated 128 500 deaths (95% uncertainty interval [UI], 104 500-155 600) among children younger than 5 years throughout the world in 2016, with 104 733 deaths occurring in sub-Saharan Africa (95% UI, 83 406-128 842). Rotavirus infection was responsible for more than 258 million episodes of diarrhea among children younger than 5 years in 2016 (95% UI, 193 million to 341 million), an incidence of 0.42 cases per child-year (95% UI, 0.30-0.53). Vaccine use is estimated to have averted more than 28 000 deaths (95% UI, 14 600-46 700) among children younger than 5 years, and expanded use of the rotavirus vaccine, particularly in sub-Saharan Africa, could have prevented approximately 20% of all deaths attributable to diarrhea among children younger than 5 years. Rotavirus-associated mortality has decreased markedly over time in part because of the introduction of the rotavirus vaccine. This study suggests that prioritizing vaccine introduction and interventions to reduce diarrhea-associated morbidity and mortality is necessary in the continued global reduction of rotavirus infection.
登录
查看更多内容
影响因子：
5.5
作者：
John, Jacob;Sarkar, Rajiv;Kang, Gagandeep
通讯作者：
Kang, Gagandeep
影响因子：
3.1
作者：
Platts-Mills, James A.;Operario, Darwin J.;Houpt, Eric R.
通讯作者：
Houpt, Eric R.
影响因子：
168.9
作者：
Kotloff, Karen L.;Nataro, James P.;Levine, Myron M.
通讯作者：
Levine, Myron M.
影响因子：
5.5
作者：
Paternina-Caicedo, Angel;Parashar, Umesh D.;De la Hoz-Restrepo, Fernando
通讯作者：
De la Hoz-Restrepo, Fernando
影响因子：
13.2
作者：
Zhen, Shan-Shan;Li, Yue;Wang, Xuan-Yi
通讯作者：
Wang, Xuan-Yi