Folic acid transport to the human fetus is decreased in pregnancies with chronic alcohol exposure.
Folic acid transport to the human fetus is decreased in pregnancies with chronic alcohol exposure.
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DOI：
10.1371/journal.pone.0038057
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Kapur BM
中科院分区：
文献类型：
--
作者：
Hutson JR;Stade B;Lehotay DC;Collier CP;Kapur BM
在怀孕期间，对叶酸的需求增加，因为胎儿需要这种营养素来快速生长和细胞增殖。胎盘将叶酸集中到胎儿循环中;因此，胎儿水平比母体水平高2至4倍。动物和体外研究表明，酒精可能通过降低转运蛋白的表达而损害叶酸通过胎盘的转运。我们的目的是确定是否叶酸转移到胎儿是改变人类怀孕与慢性饮酒。在分娩时测定孕妇血液和脐带血中的血清叶酸，慢性和重度酒精暴露孕妇（n = 23）和非饮酒对照组（n = 24）。 在酒精暴露组中，超过一半（n = 14）的胎儿∶母体血清叶酸比值≤1.0，而对照组中除一人外，其余均>1.0。 酒精暴露组脐带样本中的平均叶酸水平低于对照组（33.15±19.89 vs 45.91±20.73，p = 0.04）。 我们的研究结果表明，在怀孕期间长期大量饮酒会损害叶酸向胎儿的转运。胎盘和胎儿中叶酸浓度的改变可能部分导致胎儿酒精谱系障碍中观察到的缺陷。
During pregnancy, the demand for folic acid increases since the fetus requires this nutrient for its rapid growth and cell proliferation. The placenta concentrates folic acid into the fetal circulation; as a result the fetal levels are 2 to 4 times higher than the maternal level. Animal and in vitro studies have suggested that alcohol may impair transport of folic acid across the placenta by decreasing expression of transport proteins. We aim to determine if folate transfer to the fetus is altered in human pregnancies with chronic alcohol consumption. Serum folate was measured in maternal blood and umbilical cord blood at the time of delivery in pregnancies with chronic and heavy alcohol exposure (n = 23) and in non-drinking controls (n = 24). In the alcohol-exposed pairs, the fetal∶maternal serum folate ratio was ≤1.0 in over half (n = 14), whereas all but one of the controls were >1.0. Mean folate in cord samples was lower in the alcohol-exposed group than in the controls (33.15±19.89 vs 45.91±20.73, p = 0.04). Our results demonstrate that chronic and heavy alcohol use in pregnancy impairs folate transport to the fetus. Altered folate concentrations within the placenta and in the fetus may in part contribute to the deficits observed in the fetal alcohol spectrum disorders.
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DOI：
10.1111/j.1530-0277.2009.01106.x
发表时间：
2010-03-01
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Gundogan F;Elwood G;Mark P;Feijoo A;Longato L;Tong M;de la Monte SM
通讯作者：
de la Monte SM
DOI：
10.1097/00005176-198411000-00019
发表时间：
1984-01-01
影响因子：
2.9
作者：
NAVARRO, J;CAUSSE, MB;LALLEMAND, D
通讯作者：
LALLEMAND, D
影响因子：
7.1
作者：
Molloy, AM;Mills, JL;Ueland, PM
通讯作者：
Ueland, PM
影响因子：
5.6
作者：
Kim, Ji-Myung;Hong, Kyungju;Chang, Namsoo
通讯作者：
Chang, Namsoo
影响因子：
4.5
作者：
Gutierrez, Cristiane Minot;de Morais Ribeiro, Camila Nunes;Peres, Luiz Cesar
通讯作者：
Peres, Luiz Cesar