Ethnic differences in the prevalence of high homocysteine levels among low-income rural Kazakh and Uyghur adults in far western China and its implications for preventive public health.
Ethnic differences in the prevalence of high homocysteine levels among low-income rural Kazakh and Uyghur adults in far western China and its implications for preventive public health.
复制标题
DOI：
10.3390/ijerph120505373
复制
发表时间：
2015-05-19
影响因子：
--
通讯作者：
Ding Y
中科院分区：
文献类型：
--
作者：
Guo S;Pang H;Guo H;Zhang M;He J;Yan Y;Niu Q;Muratbek;Rui D;Li S;Ma R;Zhang J;Liu J;Ding Y
目的：同型半胱氨酸（Hcy）是血管疾病的相关生物标志物：血清Hcy浓度会增加收缩期高血压的风险，而高同型半胱氨酸血症（HHcy）与高血压有协同作用，增加心血管疾病的风险。然而，信息主要是从高收入和城市环境中收集的，对低收入农村环境知之甚少。本研究的研究对象是居住在中国西部偏远地区的低收入农村和游牧少数民族。检测Hcy水平，并调查该人群中Hcy和h型高血压的患病率。方法：本研究采用分层整群随机抽样方法，从新疆18个村庄的哈萨克族和维吾尔族居民（≥25岁）中选取2180人作为研究对象，这些村庄距离首都北京约4407公里。采用双试剂酶循环法测定Hcy水平。Hcy （Hcy > 10 μmol/L）按美国心脏协会标准定义。结果：哈萨克族Hcy几何平均值为13.34 μmol/L，维吾尔族Hcy几何平均值为13.75 μmol/L；两民族男性的平均值均高于女性（15.99 μmol/L vs. 11.63 μmol/L; 15.71 μmol/L vs. 11.91 μmol/L, p < 0.01）。两民族血清Hcy水平均随年龄增长而升高，除哈萨克族50 ~ 65岁人群外，两民族各年龄组男性血清Hcy水平均高于女性，p值均小于0.01。哈萨克族患病率为80.0%，维吾尔族患病率为78.2%；两民族男性患病率均高于女性（93.5%比69.6%；90.8%比64.6%,p < 0.05）。哈萨克族高血压患病率为35.1%，男性高于女性（44.3%比28.1%,p < 0.001）；哈萨克族人群h型高血压患病率为87.6%，男性高于女性（95.0%比80.0%,p < 0.05）。维吾尔族高血压患病率为30.6%，男性高于女性（37.9% vs. 22.8%, p < 0.001）；88.0%的维族人患有h型高血压，男性患病率高于女性（93.9%比79.1%,p < 0.05）。结论：HHcy在哈萨克族和维吾尔族人群中具有普遍性。HHcy和h型高血压的患病率在两民族中均较高，且因性别和年龄而异。应采取社区干预措施，改善新疆哈萨克族和维吾尔族的公共卫生状况。
Objective: Homocysteine (Hcy) is a relevant biomarker of vascular disease: serum Hcy concentrations will increase the risk of systolic hypertension, whereas hyperhomocysteinemia (HHcy) has a synergistic effect with hypertension and increases the risk of cardiovascular disease. However, information has primarily been gathered from high-income and urban settings, and little is known regarding low-income rural settings. This study focused on a low-income rural and nomadic minority residing in far western China. Hcy levels were tested, and the prevalences of HHcy and H-type hypertension were investigated in this population. Methods: This study used a stratified cluster random sampling method, selecting 2,180 individuals as subjects from Kazakh and Uyghur inhabitants (≥25 years old) of 18 villages in Xinjiang, China, which is approximately 4407 km from the capital, Beijing. Hcy levels were determined using a double reagent enzymatic cycling method. HHcy (Hcy > 10 μmol/L) was defined by the criteria of the American Heart Association. Results: The Kazakh geometrical mean of Hcy was 13.34 μmol/L, and the Uyghur mean was 13.75 μmol/L; the mean values were higher in males than in females of both ethnicities (15.99 μmol/L vs. 11.63 μmol/L; 15.71 μmol/L vs. 11.91 μmol/L, respectively, p < 0.01). The serum levels of Hcy increased with increasing age in both ethnicities, and except for Kazakh individuals >65 years old, Hcy serum levels were higher in males than in females in all age groups of both ethnicities, with a p value less than 0.01. The Kazakh prevalence of HHcy was 80.0%, and the Uyghur prevalence was 78.2%; the male prevalence was higher than that in females for both ethnicities (93.5% vs. 69.6%; 90.8% vs. 64.6%, respectively, p < 0.05). Among the Kazakh, the prevalence of hypertension was 35.1%, and the prevalence was higher in males than in females (44.3% vs. 28.1%, p < 0.001); 87.6% of the Kazakh individuals had H-type hypertension, and the prevalence was higher in males than in females (95.0% vs. 80.0%, p < 0.05). In Uyghur, the prevalence of hypertension was 30.6%, and the prevalence was higher in males than in females (37.9% vs. 22.8%, p < 0.001); 88.0% of the Uyghur individuals had H-type hypertension, and the prevalence was higher in males than in females (93.9% vs. 79.1%, p < 0.05). Conclusions: HHcy was found to be common among the Kazakh and Uyghur. The prevalences of HHcy and H-type hypertension were high among both ethnicities and differed depending on gender and age. Community interventions should be conducted to improve public health conditions among the Kazakh and Uyghur in Xinjiang.
登录
查看更多内容
影响因子：
3.3
作者：
Sun, Yu;Chien, Kuo-Liong;Lee, Yuan-Teh
通讯作者：
Lee, Yuan-Teh
影响因子：
168.9
作者：
Wang, LD;Kong, LZ;Burton, R
通讯作者：
Burton, R
影响因子：
168.9
作者：
Lopez, Alan D.;Mathers, Colin D.;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
影响因子：
7.7
作者：
Ilhan, Nevin;Kucuksu, Mehmet;Ozbay, Yilmaz
通讯作者：
Ozbay, Yilmaz
影响因子：
4.7
作者：
de Bree, A;van der Put, N;Ueland, PM
通讯作者：
Ueland, PM