Chromosome size affects sequence divergence between species through the interplay of recombination and selection.
Chromosome size affects sequence divergence between species through the interplay of recombination and selection.
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DOI：
10.1111/evo.14467
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发表时间：
2022-04
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影响因子：
--
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中科院分区：
文献类型：
--
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基因组的结构决定了遗传多样性和序列差异的分布。为了研究染色体大小和重组率之间的关系如何影响物种间的序列差异，我们结合了经验分析和进化模拟。我们从染色体水平的基因组组装中估计了来自三个不同哺乳动物分支的15个物种之间的成对序列差异-Peromyscus啮齿动物，Mus小鼠和大猩猩。我们发现一个强大的显着负相关的染色体大小和序列分歧在所有物种的比较内的Peromyscus和类人猿分支，但不是小鼠分支，这表明小鼠物种之间的戏剧性的染色体重排可能掩盖了祖先的基因组景观的分歧在许多比较。我们的进化模拟表明，决定不同大小的染色体之间分歧的主要因素是重组率和选择的相互作用，在较大的群体比在较小的群体有更大的变化。在祖先群体中，较短的染色体具有更大的核苷酸多样性。随着祖先种群的分化，分裂开始时存在的多样性导致子代物种中较短染色体的序列差异更大。经验数据和进化模拟的结合揭示了染色体重排、人口统计学和分化时间也可能影响染色体大小和分化之间的关系，从而加深了我们对基因组结构在物种分化进化中的作用的理解。
The structure of the genome shapes the distribution of genetic diversity and sequence divergence. To investigate how the relationship between chromosome size and recombination rate affects sequence divergence between species, we combined empirical analyses and evolutionary simulations. We estimated pairwise sequence divergence among 15 species from three different mammalian clades—Peromyscus rodents, Mus mice, and great apes—from chromosome‐level genome assemblies. We found a strong significant negative correlation between chromosome size and sequence divergence in all species comparisons within the Peromyscus and great apes clades but not the Mus clade, suggesting that the dramatic chromosomal rearrangements among Mus species may have masked the ancestral genomic landscape of divergence in many comparisons. Our evolutionary simulations showed that the main factor determining differences in divergence among chromosomes of different sizes is the interplay of recombination rate and selection, with greater variation in larger populations than in smaller ones. In ancestral populations, shorter chromosomes harbor greater nucleotide diversity. As ancestral populations diverge, diversity present at the onset of the split contributes to greater sequence divergence in shorter chromosomes among daughter species. The combination of empirical data and evolutionary simulations revealed that chromosomal rearrangements, demography, and divergence times may also affect the relationship between chromosome size and divergence, thus deepening our understanding of the role of genome structure in the evolution of species divergence.
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影响因子：
10.7
作者：
Farré M;Micheletti D;Ruiz-Herrera A
通讯作者：
Ruiz-Herrera A
影响因子：
5
作者：
Delmore KE;Lugo Ramos JS;Van Doren BM;Lundberg M;Bensch S;Irwin DE;Liedvogel M
通讯作者：
Liedvogel M
影响因子：
4.9
作者：
Dion-Cote, Anne-Marie;Symonova, Radka;Bernatchez, Louis
通讯作者：
Bernatchez, Louis
DOI：
10.1073/pnas.1416622112
发表时间：
2015-02-17
影响因子：
11.1
作者：
Arbeithuber, Barbara;Betancourt, Andrea J.;Tiemann-Boege, Irene
通讯作者：
Tiemann-Boege, Irene
影响因子：
7.7
作者：
Colella, Jocelyn P.;Tigano, Anna;MacManes, Matthew D.
通讯作者：
MacManes, Matthew D.