The fundamental role of endothelial cells in hantavirus pathogenesis.
The fundamental role of endothelial cells in hantavirus pathogenesis.
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DOI:
10.3389/fmicb.2014.00727
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发表时间:
2014
影响因子:
5.2
通讯作者:
Strandin T
中科院分区:
文献类型:
--
作者:
Hepojoki J;Vaheri A;Strandin T
Hantavirus, a genus of rodent- and insectivore-borne viruses in the family Bunyaviridae, is a group of emerging zoonotic pathogens. Hantaviruses cause hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome in man, often with severe consequences. Vascular leakage is evident in severe hantavirus infections, and increased permeability contributes to the pathogenesis. This review summarizes the current knowledge on hantavirus interactions with hematopoietic and endothelial cells, and their effects on the increased vascular permeability.
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