The fundamental role of endothelial cells in hantavirus pathogenesis.

The fundamental role of endothelial cells in hantavirus pathogenesis.
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DOI:
10.3389/fmicb.2014.00727
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发表时间:
2014
影响因子:
5.2
通讯作者:
Strandin T
Strandin T
中科院分区:
生物学2区
文献类型:
--
作者:
Hepojoki J;Vaheri A;Strandin T

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汉坦病毒(Hantavirus)是布尼亚病毒科(Bunyaviridae)啮齿动物和食虫动物传播的病毒,是一组新出现的人畜共患病原体。汉坦病毒可引起人类肾综合征出血热和汉坦病毒心肺综合征,通常具有严重的后果。血管渗漏在严重的汉坦病毒感染中是明显的,并且增加的通透性有助于发病机制。本文综述了汉坦病毒与造血细胞和内皮细胞的相互作用及其对血管通透性增加的影响。
Hantavirus, a genus of rodent- and insectivore-borne viruses in the family Bunyaviridae, is a group of emerging zoonotic pathogens. Hantaviruses cause hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome in man, often with severe consequences. Vascular leakage is evident in severe hantavirus infections, and increased permeability contributes to the pathogenesis. This review summarizes the current knowledge on hantavirus interactions with hematopoietic and endothelial cells, and their effects on the increased vascular permeability.
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