Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid-life: A randomized trial.
Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid-life: A randomized trial.
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DOI：
10.1002/alz.12421
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发表时间：
2022-03
影响因子：
14
通讯作者：
Craft, Suzanne
中科院分区：
文献类型：
--
作者：
Hoscheidt, Siobhan;Sanderlin, Ashley H.;Baker, Laura D.;Jung, Youngkyoo;Lockhart, Samuel;Kellar, Derek;Whitlow, Christopher;Hanson, Angela J.;Friedman, Seth;Register, Thomas;Leverenz, James B.;Craft, Suzanne
中年饮食模式与阿尔茨海默病（AD）风险相关，尽管很少进行对照试验。87名认知正常（NC，n = 56）或轻度认知障碍（MCI，n = 31）的受试者（年龄范围：45至65岁）接受了4周的等热量饮食（饱和脂肪、血糖指数和钠含量高或低）（西式/西式饮食vs地中海式/地中海式饮食）。评估饮食对脑脊液（CSF）生物标志物、认知和脑灌注的影响，以确定认知状态是否会导致反应不同。对于NC成人，中等饮食后CSF淀粉样蛋白β（Aβ）42/40比值增加，而西方饮食后降低，而MCI组显示相反的模式。对于MCI组，West‐饮食减少，Med‐饮食增加总tau（t-tau），而CSF Aβ42/t-tau比值在West‐饮食后增加，在Med‐饮食后降低。对于NC受试者，中等饮食增加，西方饮食减少脑灌注。中年时期的饮食反应可能突出了增加AD风险的早期病理生理过程。
Mid‐life dietary patterns are associated with Alzheimer's disease (AD) risk, although few controlled trials have been conducted. Eighty‐seven participants (age range: 45 to 65) with normal cognition (NC, n = 56) or mild cognitive impairment (MCI, n = 31) received isocaloric diets high or low in saturated fat, glycemic index, and sodium (Western‐like/West‐diet vs. Mediterranean‐like/Med‐diet) for 4 weeks. Diet effects on cerebrospinal fluid (CSF) biomarkers, cognition, and cerebral perfusion were assessed to determine whether responses differed by cognitive status. CSF amyloid beta (Aβ)42/40 ratios increased following the Med‐diet, and decreased after West‐diet for NC adults, whereas the MCI group showed the reverse pattern. For the MCI group, the West‐diet reduced and the Med‐diet increased total tau (t‐tau), whereas CSF Aβ42/t‐tau ratios increased following the West‐diet and decreased following the Med‐diet. For NC participants, the Med‐diet increased and the West‐diet decreased cerebral perfusion. Diet response during middle age may highlight early pathophysiological processes that increase AD risk.
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影响因子：
4.2
作者：
Dai W;Duan W;Alfaro FJ;Gavrieli A;Kourtelidis F;Novak V
通讯作者：
Novak V
影响因子：
29
作者：
Hanson, Angela J.;Bayer-Carter, Jennifer L.;Green, Pattie S.;Montine, Thomas J.;Wilkinson, Charles W.;Baker, Laura D.;Watson, Stennis;Bonner, Laura M.;Callaghan, Maureen;Leverenz, James B.;Tsai, Elaine;Postupna, Nadia;Zhang, Jing;Lampe, Johanna;Craft, Suzanne
通讯作者：
Craft, Suzanne
影响因子：
4.8
作者：
Bangen KJ;Clark AL;Edmonds EC;Evangelista ND;Werhane ML;Thomas KR;Locano LE;Tran M;Zlatar ZZ;Nation DA;Bondi MW;Delano-Wood L
通讯作者：
Delano-Wood L
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
DOI：
10.1016/s0022-5371(73)80034-9
发表时间：
1973-01-01
期刊：
JOURNAL OF VERBAL LEARNING AND VERBAL BEHAVIOR
影响因子：
--
作者：
BUSCHKE, H
通讯作者：
BUSCHKE, H