The resting perfusion pattern associates with functional decline in type 2 diabetes.
The resting perfusion pattern associates with functional decline in type 2 diabetes.
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DOI：
10.1016/j.neurobiolaging.2017.09.004
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发表时间：
2017-12
影响因子：
4.2
通讯作者：
Novak V
中科院分区：
文献类型：
--
作者：
Dai W;Duan W;Alfaro FJ;Gavrieli A;Kourtelidis F;Novak V
我们研究了两年内 2 型糖尿病 (T2DM) 患者脑血流量 (CBF)、认知能力和活动能力下降之间的关系。 73 名参与者（41 名 T2DM 和 32 名对照）在基线和两年随访时使用体积 CBF 和动脉自旋标记 (ASL) 灌注磁共振成像 (pMRI) 进行评估。使用体素分析检测 T2DM 参与者和对照组之间在基线时 CBF 存在显着差异的区域。进行相关分析以调查两年内区域 CBF 与认知或活动能力之间的关联。与对照组相比，T2DM 参与者在静息状态默认模式、视觉和小脑网络中的 CBF 降低。两年内这些区域的纵向 CBF 值下降幅度更大，与步态、记忆和执行功能较差、基线胰岛素抵抗较高和基线认知表现较差相关。在 T2DM 中，静息区域灌注受损与较差的认知和活动能力密切相关。胰岛素抵抗可能进一步导致 T2DM 的局部灌注不足。
We investigated the relationships between cerebral blood flow (CBF), cognitive and mobility decline in type 2 diabetes mellitus (T2DM) over a two-year period. Seventy-three participants (41 T2DM and 32 controls) were evaluated using volumetric CBF with arterial spin labeling (ASL) perfusion magnetic resonance imaging (pMRI) at baseline and at the two-year follow-up. Regions with significant CBF differences between T2DM participants and controls at baseline were detected using voxel-wise analysis. Correlation analysis was performed to investigate the association between regional CBF and cognitive or mobility performance over the two-year span. Compared to controls, participants with T2DM had decreased CBF in the resting state default mode, visual, and cerebellum networks. Greater decrease in longitudinal CBF values at these regions over a two-year span was associated with worse gait, memory and executive functions, and higher baseline insulin resistance and worse baseline cognitive performance. In T2DM, impairment of resting regional perfusion is closely related to worse cognitive and mobility performance. Insulin resistance may further contribute to regional perfusion deficit in T2DM.
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影响因子：
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