Relationship between gut microbiota and nutritional status in patients on peritoneal dialysis.
Relationship between gut microbiota and nutritional status in patients on peritoneal dialysis.
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DOI：
10.1038/s41598-023-27919-3
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发表时间：
2023-01-28
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
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作者：
营养不良是透析人群（血液透析和腹膜透析（PD））的常见并发症。我们报告我们的探索性研究的特点，肠道菌群和营养状况的PD患者。对PD患者的营养状况进行评估，并收集其粪便进行16 S rRNA基因V3-V4区扩增和高通量测序。比较营养良好组（W）和营养不良组（M）的微生物群特征和差异。我们研究了我们的患者的属和属内的操作分类单位（OTU），最初比较营养不良组和营养良好组，随后使用这些OTU重新分析整个组。在OTU水平上，有6种细菌与血清白蛋白水平显著相关。W群中OTU 208（Lachnospiaceae_incertae_sedi）和OTU 4（Bacteroides）的丰度较高。M群中4种OTU（OTU 225 Akkermansia、OTU 87 Megaspaera、OTU 31 Peptostreptococcaceae_incertae_sedi和OTU 168 Clostridium_sensu_strictu）的个体间丰度较高。值得注意的是，OTU 168 Clostridium_sensu_stricto是唯一与血清白蛋白（r =-0.356，P = 0.05）、前白蛋白（r =-0.399，P = 0.02）和SGA（r = 0.458，P = 0.01）显著相关的细菌。OTU 168狭义梭菌越高，血清白蛋白和前白蛋白越低，SGA评分越高，表明营养状况越差。我们的初步研究结果表明PD患者的营养状况与微生物群之间存在关系。我们的研究结果为进一步探索PD患者营养不良和肠道植物群之间的相互作用提供了基础，并可能使用益生菌和益生元进行干预。
Malnutrition is a common complication in the dialysis population, both hemodialysis and peritoneal dialysis (PD). We report our exploratory study on the characteristics of intestinal microbiota and nutritional status in PD patients. The nutritional status of our PD patients were evaluated, and their feces were collected for 16S rRNA gene V3-V4 regions amplification and high-throughput sequencing. The characteristics and differences of microbiota between the well-nourished (W) and malnourished (M) groups were compared. We studied the genera and the operational taxonomic units (OTUs) within the genus of our patients, initially comparing the malnourished and the well- nourished groups and later on reanalyzing the whole group using these OTUs. At the OTU level, 6 bacteria were significantly correlated with the serum albumin level. The abundances of 2 OTUs (OTU208 Lachnospiraceae_incertae_sedi and OTU4 Bacteroides) were more in W group. Meanwhile, 4 OTUs (OTU225 Akkermansia, OTU87 Megasphaera, OTU31 Peptostreptococcaceae_incertae_sedi and OTU168 Clostridium_sensu_strictu) displayed higher abundance among individuals in M group. Notably, the OTU168 Clostridium_sensu_stricto was the only bacteria that significantly correlated with serum albumin (r = − 0.356, P = 0.05), pre-albumin (r = − 0.399, P = 0.02), and SGA (r = 0.458, P = 0.01). The higher the OTU168 Clostridium_sensu_strictu, the lower serum albumin and pre-albumin and a higher score of SGA signifying a worse nutritional status. Our preliminary findings suggested a relationship between the nutrition status and microbiota in PD patients. Our results provide a basis for further exploration of the interactions between malnutrition and intestinal flora in PD patients with potential interventions using probiotics and prebiotics.
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影响因子：
2.3
作者：
Hu J;Zhong X;Liu Y;Yan J;Zhou D;Qin D;Xiao X;Zheng Y;Wen L;Tan R;Liang P;Liu Y
通讯作者：
Liu Y
影响因子：
8.2
作者：
Allin KH;Tremaroli V;Caesar R;Jensen BAH;Damgaard MTF;Bahl MI;Licht TR;Hansen TH;Nielsen T;Dantoft TM;Linneberg A;Jørgensen T;Vestergaard H;Kristiansen K;Franks PW;IMI-DIRECT consortium;Hansen T;Bäckhed F;Pedersen O
通讯作者：
Pedersen O
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
4.6
作者：
Nagpal R;Wang S;Ahmadi S;Hayes J;Gagliano J;Subashchandrabose S;Kitzman DW;Becton T;Read R;Yadav H
通讯作者：
Yadav H
影响因子：
2.3
作者：
Ma, Terry King-Wing;Chow, Kai Ming;Szeto, Cheuk Chun
通讯作者：
Szeto, Cheuk Chun