Protein Ontology: a controlled structured network of protein entities.
Protein Ontology: a controlled structured network of protein entities.
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DOI：
10.1093/nar/gkt1173
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发表时间：
2014-01
影响因子：
14.9
通讯作者：
Wu CH
中科院分区：
文献类型：
--
作者：
Natale DA;Arighi CN;Blake JA;Bult CJ;Christie KR;Cowart J;D'Eustachio P;Diehl AD;Drabkin HJ;Helfer O;Huang H;Masci AM;Ren J;Roberts NV;Ross K;Ruttenberg A;Shamovsky V;Smith B;Yerramalla MS;Zhang J;AlJanahi A;Çelen I;Gan C;Lv M;Schuster-Lezell E;Wu CH
蛋白质本体论（PRO; http://proconsortium.org）正式定义了蛋白质实体，并明确表示了它们的主要形式和相互关系。以PRO表示的对应于单个氨基酸链的蛋白质实体按特异性水平分类为家族、基因、序列和修饰元类，并且蛋白质复合物有单独的元类。所有的元类也都有生物体特定的衍生物。PRO补充了已建立的序列数据库，如UniProtKB，并与其他生物医学和生物本体，如基因本体（GO）进行互操作。PRO与UniProtKB相关，因为PRO的由特定基因编码的生物体特异性蛋白质类对应于UniProtKB条目中记录的实体。PRO与GO相关，因为PRO对生物体特异性蛋白质复合物的表示是GO细胞组分本体中生物体不可知蛋白质复合物术语的子类。在过去的几年里，PRO经历了成长和变化，以及PRO在免疫学和蛋白质组学中的新数据获取点和新应用。我们在此描述其中的一些发展。
The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments.
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影响因子：
3
作者：
Bada M;Eckert M;Evans D;Garcia K;Shipley K;Sitnikov D;Baumgartner WA Jr;Cohen KB;Verspoor K;Blake JA;Hunter LE
通讯作者：
Hunter LE
影响因子：
4.3
作者：
Reference Genome Group of the Gene Ontology Consortium
通讯作者：
Reference Genome Group of the Gene Ontology Consortium
影响因子：
46.9
作者：
Smith, Barry;Ashburner, Michael;Lewis, Suzanna
通讯作者：
Lewis, Suzanna
影响因子：
3.7
作者：
Ross KE;Arighi CN;Ren J;Natale DA;Huang H;Wu CH
通讯作者：
Wu CH
影响因子：
64.8
作者：
Tran, John C.;Zamdborg, Leonid;Ahlf, Dorothy R.;Lee, Ji Eun;Catherman, Adam D.;Durbin, Kenneth R.;Tipton, Jeremiah D.;Vellaichamy, Adaikkalam;Kellie, John F.;Li, Mingxi;Wu, Cong;Sweet, Steve M. M.;Early, Bryan P.;Siuti, Nertila;LeDuc, Richard D.;Compton, Philip D.;Thomas, Paul M.;Kelleher, Neil L.
通讯作者：
Kelleher, Neil L.