Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study.
Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study.
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DOI：
10.1038/srep39471
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发表时间：
2017-01-03
影响因子：
4.6
通讯作者：
Train the Brain Consortium
中科院分区：
文献类型：
--
作者：
Train the Brain Consortium
与年龄相关的认知障碍和痴呆症是日益增加的社会负担。流行病学研究表明，生活方式因素，例如体力、认知和社交活动与痴呆风险降低相关；此外，在认知未受损的老年人中发现身体/认知训练对认知有积极影响。对于已经患有轻度认知障碍（MCI）的老年人（痴呆症高危人群）的身体/认知训练的有效性和作用机制知之甚少。我们在 113 名 65-89 岁的 MCI 受试者中评估了身体认知联合训练对海马和海马旁区域认知衰退、灰质 (GM) 容量减少和脑血流量 (CBF) 以及认知任务引起的脑血氧水平依赖性 (BOLD) 活动的功效，通过 ADAS-Cog 量表、磁共振成像进行测量 (MRI)、动脉旋转标记 (ASL) 和功能磁共振成像，分别为 7 个月训练前后与日常生活对比。未接受 MCI 训练的受试者的认知状态显着下降，而接受 MCI 训练的受试者的认知状态显着提高；训练增加了海马旁 CBF，但对 GM 体积损失没有明显影响；仅在未进行 MCI 训练的受试者中才发现 BOLD 活动增加，表明神经效率下降。这些结果表明，非药物、多成分干预可改善 MCI 受试者的认知状态和大脑健康指标。
Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65–89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippocampal areas, and on brain-blood-oxygenation-level-dependent (BOLD) activity elicited by a cognitive task, measured by ADAS-Cog scale, Magnetic Resonance Imaging (MRI), Arterial Spin Labeling (ASL) and fMRI, respectively, before and after 7 months of training vs. usual life. Cognitive status significantly decreased in MCI-no training and significantly increased in MCI-training subjects; training increased parahippocampal CBF, but no effect on GM volume loss was evident; BOLD activity increase, indicative of neural efficiency decline, was found only in MCI-no training subjects. These results show that a non pharmacological, multicomponent intervention improves cognitive status and indicators of brain health in MCI subjects.
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影响因子：
9.9
作者：
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通讯作者：
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影响因子：
3.6
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
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通讯作者：
Kramer, Arthur F.