The mechanism of acute fasting-induced antidepressant-like effects in mice.
The mechanism of acute fasting-induced antidepressant-like effects in mice.
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DOI：
10.1111/jcmm.13310
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发表时间：
2018-01
影响因子：
5.3
通讯作者：
Li B
中科院分区：
文献类型：
--
作者：
Cui R;Fan J;Ge T;Tang L;Li B
急性禁食诱导的抗抑郁样作用。然而，这些行动的确切大脑区域和机制在很大程度上仍然未知。因此，在本研究中，研究了急性禁食对c-Fos表达和BDNF水平的抗抑郁样作用。与我们以前的研究结果一致，在强迫游泳试验中禁食9小时显著缩短了不动时间。此外，9禁食的这些抗抑郁样作用可被5-HT 2A/2C受体激动剂（±）-1-（2，5-二甲氧基-4-碘苯基）-2-氨基丙烷盐酸盐（DOI）抑制，并且DOI的作用可通过预处理而被阻断选择性5-HT 2A受体拮抗剂酮色林。免疫组织化学研究表明，c-Fos水平在前额叶皮层中显著增加，但在海马和缰核中没有显著增加。空腹诱导的c-Fos表达通过前额叶皮质中的DOI进一步增强，而这些增强被酮色林抑制。DOI可明显抑制禁食引起的额叶皮层和海马BDNF水平的升高，DOI对BDNF水平的影响也可被酮色林阻断。这些发现表明，急性禁食的抗抑郁样作用可能是通过5-HT 2A受体发挥的，并且对前额叶皮层的神经活动特别敏感。此外，这些抗抑郁样作用也由海马和额叶皮质中的CREB和BDNF通路介导。因此，禁食可能有助于对抗抑郁症。
Acute fasting induced antidepressant‐like effects. However, the exact brain region and mechanism of these actions are still largely unknown. Therefore, in this study the antidepressant‐like effects of acute fasting on c‐Fos expression and BDNF levels were investigated. Consistent with our previous findings, immobility time was remarkably shortened by 9 hrs fasting in the forced swimming test. Furthermore, these antidepressant‐like effects of 9 fasting were inhibited by a 5‐HT 2A/2C receptor agonist (±)‐1‐(2, 5‐dimethoxy‐4‐iodophenyl)‐2‐aminopropane hydrochloride (DOI), and the effect of DOI was blocked by pretreatment with a selective 5‐HT 2A receptor antagonist ketanserin. Immunohistochemical study has shown that c‐Fos level was significantly increased by 9 hrs fasting in prefrontal cortex but not hippocampus and habenular. Fasting‐induced c‐Fos expression was further enhanced by DOI in prefrontal cortex, and these enhancements were inhibited by ketanserin. The increased BDNF levels by fasting were markedly inhibited by DOI in frontal cortex and hippocampus, and these effects of DOI on BDNF levels were also blocked by ketanserin. These findings suggest that the antidepressant‐like effects of acute fasting may be exerted via 5‐HT 2A receptor and particularly sensitive to neural activity in the prefrontal cortex. Furthermore, these antidepressant‐like effects are also mediated by CREB and BDNF pathway in hippocampus and frontal cortex. Therefore, fasting may be potentially helpful against depression.
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影响因子：
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作者：
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