Nurturing the cortex's thalamic nature.
Nurturing the cortex's thalamic nature.
复制标题
培育皮质的丘脑性质。
DOI：
10.1097/wco.0000000000000070
复制
发表时间：
2014
影响因子：
4.8
通讯作者：
D. Jabaudon
中科院分区：
文献类型：
--
作者：
Gabrielle Pouchelon;D. Jabaudon
综述目的
新皮层和丘脑的相互作用是执行复杂的感觉运动任务和相关的认知过程所必需的。因此，研究丘脑皮层回路的发育对于了解涉及异常皮层功能的发育障碍至关重要。在这里，我们回顾最近的进展，我们了解丘脑依赖的皮层图案和皮层神经元分化。
最近的调查结果
虽然越来越多地了解皮层地图图案的原则，丘脑皮质输入在多大程度上有助于皮层神经元分化仍然不清楚。最近发展的遗传模型，允许细胞类型特异性解剖皮层输入途径，揭示了一些输入依赖性和活动依赖性的过程中发生的皮质发育，这是在这里讨论。
总结
这些最近的研究揭示了丘脑和皮层神经元之间的交织联系，其中细胞内在分化程序在长时间的发育过程中受到突触输入的严格调控。未来几年的挑战将是确定内在和外在分化程序之间相互作用的机制，以及它们对神经发育障碍和神经精神障碍的贡献。
PURPOSE OF REVIEW
Neocortical and thalamic interactions are necessary for the execution of complex sensory-motor tasks and associated cognitive processes. Investigation of thalamocortical circuit development is therefore critical to understand developmental disorders involving abnormal cortical function. Here, we review recent advances in our understanding of thalamus-dependent cortical patterning and cortical neuron differentiation.
RECENT FINDINGS
Although the principles of cortical map patterning are increasingly understood, the extent to which thalamocortical inputs contribute to cortical neuron differentiation is still unclear. The recent development of genetic models allowing cell-type-specific dissection of cortical input pathways has shed light on some of the input-dependent and activity-dependent processes occurring during cortical development, which are discussed here.
SUMMARY
These recent studies have revealed interwoven links between thalamic and cortical neurons, in which cell intrinsic differentiation programs are tightly regulated by synaptic input during a prolonged period of development. Challenges in the years to come will be to identify the mechanisms underlying the reciprocal interactions between intrinsic and extrinsic differentiation programs, and their contribution to neurodevelopmental disorders and neuropsychiatric disorders at large.
DOI：
10.1073/pnas.1218330110
发表时间：
2013-05-07
影响因子：
11.1
作者：
Harsan, Laura-Adela;David, Csaba;Staiger, Jochen F.
通讯作者：
Staiger, Jochen F.
DOI：
10.1073/pnas.96.16.9397
发表时间：
1999-08-03
影响因子：
11.1
作者：
Maier, DL;Mani, S;Meiri, KF
通讯作者：
Meiri, KF
DOI：
10.1073/pnas.92.24.11244
发表时间：
1995-11-21
影响因子：
11.1
作者：
HERRMANN, K;SHATZ, CJ
通讯作者：
SHATZ, CJ