Toxicological Evaluation of Acetylsalicylic Acid in Non-Target Organisms: Chronic Exposure on Mytilus galloprovincialis (Lamarck, 1819).
Toxicological Evaluation of Acetylsalicylic Acid in Non-Target Organisms: Chronic Exposure on Mytilus galloprovincialis (Lamarck, 1819).
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DOI：
10.3389/fphys.2022.920952
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发表时间：
2022
影响因子：
4
通讯作者：
Faggio, C.
中科院分区：
文献类型：
--
作者：
Pagano, M.;Savoca, S.;Impellitteri, F.;Albano, M.;Capillo, G.;Faggio, C.
药物现在被认为是确定的污染物，它们在水中的存在不仅对海洋生态系统构成真实的风险，因为它们可能对接触到它们的非目标生物产生不利影响，而且还间接对人类产生不利影响。这是特别真实的模式生物在这项工作中考虑，贻贝galloprovincialis，悬浮和生物积累的有机体，进入人类食物链。在最常用的非处方药中，抗炎药无疑具有突出的特点，其中乙酰水杨酸（阿萨）位居榜首。在这项工作中，M。将galloprovincialis标本暴露于两种浓度的阿萨（10和100 μg/L）10和20天，以评估消化腺细胞的调节体积（RVD）减少以及这些细胞和血细胞的细胞活力的可能变化。此外，还对鳃和消化腺的组织病理学指标进行了评价。获得的数据表明，长期接触阿萨并没有改变血细胞和消化腺细胞的细胞活力，但改变了消化腺体积调节的生理机制，此外，在鳃和消化腺中发现阿萨的时间-剂量反应，表现出许多变化，如脂褐质沉积和血细胞浸润。强调有必要加深对非处方药与非目标生物体之间联系的了解。
Pharmaceuticals are now considered to be established contaminants, and their presence in water poses a real risk not only to the marine ecosystem, as they may adversely affect non-target organisms that are exposed to them, but also indirectly to humans. This is particularly true for the model organism considered in this work, Mytilus galloprovincialis, a suspensivore and bioaccumulating organism that enters the human food chain. Among the most commonly used over-the-counter medicines, anti-inflammatory drugs certainly feature prominently, with acetylsalicylic acid (ASA) at the top. In this work, M. galloprovincialis specimens were exposed to two concentrations of ASA (10 and 100 μg/L) for 10 and 20 days to evaluate possible alterations in the decrease in regulatory volume (RVD) in digestive gland cells and cell viability of both these cells and hemocytes. In addition, the histopathological condition index of the gills and digestive gland was evaluated. The data obtained showed that chronic exposure to ASA did not alter the cell viability of hemocytes and digestive gland cells but alters the physiological mechanisms of volume regulation in the digestive gland and, in addition, a time-dose reaction to ASA in the gills and digestive gland showing numerous alterations such as lipofuscin deposits and hemocyte infiltration was found. These results confirm the potential toxicity to the marine biota, highlighting the necessity to deepen the knowledge regarding the link between over-the-counter pharmaceuticals and non-target organisms.
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影响因子：
5.4
作者：
Deeds JR;Landsberg JH;Etheridge SM;Pitcher GC;Longan SW
通讯作者：
Longan SW
DOI：
10.1016/s0300-9629(97)00017-0
发表时间：
1997-11-01
影响因子：
2.3
作者：
Auffret, M;Oubella, R
通讯作者：
Oubella, R
影响因子：
4
作者：
Caricato R;Giordano ME;Schettino T;Lionetto MG
通讯作者：
Lionetto MG
影响因子：
5.4
作者：
Capillo, Gioele;Savoca, Serena;Faggio, Caterina
通讯作者：
Faggio, Caterina
影响因子：
4.5
作者：
Faggio, Caterina;Pagano, Maria;Felice, Maria Rosa
通讯作者：
Felice, Maria Rosa