Natural killer cells in intracranial neoplasms: presence and therapeutic efficacy against brain tumours.
Natural killer cells in intracranial neoplasms: presence and therapeutic efficacy against brain tumours.
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DOI：
10.1007/s11060-013-1265-5
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发表时间：
2014-01
影响因子：
3.9
通讯作者：
Chekenya, Martha
中科院分区：
文献类型：
--
作者：
Kmiecik, Justyna;Zimmer, Jacques;Chekenya, Martha
自然杀伤（NK）细胞是在抗肿瘤免疫中发挥重要作用的淋巴细胞。它们在体外和体内作为直接抗肿瘤剂和刺激内源性NK细胞细胞毒性的实验疗法中对脑癌的潜力已得到证实。然而，这些有希望的结果的临床转化需要详细了解脑肿瘤患者的免疫状态，重点是NK细胞群。在这份报告中，我们提供了一个概述的研究调查NK细胞浸润到肿瘤中，强调需要修改的方法和在这一领域的进一步研究。我们还讨论了使用自体或同种异体NK细胞作为效应细胞在细胞疗法中对抗脑癌的潜力，以及开发刺激内源性NK细胞介导的抗肿瘤反应的免疫疗法，例如阻断抑制性杀伤免疫球蛋白样受体。NK细胞过继转移与靶向治疗（如抗EGFR治疗性抗体（CetuximAb））的组合也可能是有效的策略。
Natural killer (NK) cells are lymphocytes that play an important role in anti-tumour immunity. Their potential against brain cancer has been demonstrated in vitro and in vivo, both as a direct anti-tumour agent and in experimental therapies stimulating endogenous NK cell cytotoxicity. However, the clinical translation of these promising results requires detailed knowledge about the immune status of brain tumour patients, with focus on the NK cell population. In this report, we provide an overview of the studies investigating NK cell infiltration into the tumour, emphasizing the need of revision of the methodologies and further research in this field. We also discuss the potential of using autologous or allogeneic NK cells as effector cells in cellular therapy against brain cancer and developing immunotherapies stimulating endogenous NK cell-mediated anti-tumour response, such as blocking inhibitory killer immunoglobulin-like receptors. Combination of NK cell adoptive transfer with targeted therapies, such as anti-EGFR therapeutic antibody (CetuximAb) could also be a potent strategy.
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影响因子：
20.3
作者：
Benson, Don M., Jr.;Hofmeister, Craig C.;Farag, Sherif S.
通讯作者：
Farag, Sherif S.
DOI：
10.1084/jem.187.5.813
发表时间：
1998-03-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Borrego F;Ulbrecht M;Weiss EH;Coligan JE;Brooks AG
通讯作者：
Brooks AG
影响因子：
2.7
作者：
Kondo, E;Koda, K;Miyazaki, M
通讯作者：
Miyazaki, M
影响因子：
6.4
作者：
Avril, Tony;Vauleon, Elodie;Quillien, Veronique
通讯作者：
Quillien, Veronique
影响因子：
15.9
作者：
Dolecek, Therese A.;Propp, Jennifer M.;Kruchko, Carol
通讯作者：
Kruchko, Carol