Apolipoprotein Ε ε4 frequency is increased among Chinese patients with frontotemporal dementia and Alzheimer's disease.
Apolipoprotein Ε ε4 frequency is increased among Chinese patients with frontotemporal dementia and Alzheimer's disease.
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DOI：
10.1159/000350872
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发表时间：
2013
影响因子：
2.4
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Ji Y;Liu M;Huo YR;Liu S;Shi Z;Liu S;Wisniewski T;Wang J
载脂蛋白E（ApoE）ε4基因型与阿尔茨海默病（AD）风险增加之间的关系在高加索人中已得到充分证实，但在其他种族中则不太确定。ApoE ε4也与其他几种神经系统疾病有关。ApoE4 ε4是否是额颞叶痴呆（FTD）的危险因素仍存在争议。该研究检查了432例AD患者、62例FTD患者和381例性别和年龄匹配的对照。与对照组相比，AD和FTD组患者的ApoE ε4等位基因频率显著增加。ApoE ε4等位基因的频率在晚发性AD中为24.86%（p < 0.01），在早发性AD中为18.02%（p < 0.01），在FTD中为16.13%（p < 0.01），在对照组中为7.34%。FTD和AD组的ApoE ε4患病率相似。目前的研究表明，ApoE ε4等位基因是这两种疾病的危险因素。
The relationship between the apolipoprotein E (ApoE) ε4 genotype and an increased risk of developing Alzheimer’s disease (AD) has been well established in Caucasians but is less established among other ethnicities. ApoE ε4 has also been associated with several other neurological disorders. Whether ApoE4 ε4 is a risk factor for frontotemporal dementia (FTD) remains controversial. This study examined 432 patients with AD, 62 with FTD, and 381 sex- and age-matched controls. The ApoE ε4 allele frequency was significantly increased among patients in the AD and FTD groups compared with controls. The frequency of the ApoE ε4 allele was 24.86% in late-onset AD (p < 0.01), 18.02% in early-onset AD (p < 0.01), 16.13% in FTD (p < 0.01), and 7.34% in controls. ApoE ε4 prevalence was similar in the FTD and AD groups. The present study suggests that the ApoE ε4 allele is a risk factor for both disorders.
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