Curcumin-Mediated Cardiac Defects in Mouse is Associated with a Reduced Histone H3 Acetylation and Reduced Expression of Cardiac Transcription Factors
Curcumin-Mediated Cardiac Defects in Mouse is Associated with a Reduced Histone H3 Acetylation and Reduced Expression of Cardiac Transcription Factors
复制标题
姜黄素介导的小鼠心脏缺陷与组蛋白 H3 乙酰化减少和心脏转录因子表达减少有关
DOI：
10.1007/s12012-013-9240-0
复制
发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Huichao Sun,Jie Tian
中科院分区：
文献类型：
--
作者：
Huichao Sun,Jie Tian
Histone acetylation plays an important role in heart development. However, the mechanism(s) remains unclear. This study was designed to evaluate the effect of curcumin-caused histone hypo-acetylation on the development of mouse embryonic heart and the expression of cardiac transcription factors in vivo. The results showed that curcumin treatment significantly decreased histone acetylase activity and histone acetylation level in mouse embryonic heart. In curcumin-treated mice, the hearts on E11.5 were smaller with thinner ventricular wall and a delayed development of trabeculae and ventricular septum compared with the controls. The ventricular septum was complete on E14.5; however, the ventricular wall and septum were thinner with fewer trabeculae than those in the controls. On E17.5, the cardiac structure appeared normal, but the ventricular wall and septum were thinner. The expression of GATA4, Nkx2.5 and Mef2c in the heart on E11.5 and E14.5 was decreased significantly as compared to the controls. There was no significant difference in Mef2c expression on E17.5 between curcumin-treated group and the controls, while GATA4 and Nkx2.5 expression remained significantly reduced. These results indicate that inhibition of histone acetylation by curcumin can reduce the expression of the cardiac transcription factors resulting in an abnormal heart development in mice.
登录
查看更多内容
影响因子：
2.7
作者：
Targoff, Kimara L.;Schell, Thomas;Yelon, Deborah
通讯作者：
Yelon, Deborah
DOI：
--
发表时间：
2008
期刊：
--
影响因子：
--
作者：
Nikki Gillum;N. Sarvazyan
通讯作者：
Nikki Gillum;N. Sarvazyan
影响因子：
64.5
作者：
Lee JS;Smith E;Shilatifard A
通讯作者：
Shilatifard A
影响因子：
4.8
作者：
Balasubramanyam, K;Varier, RA;Kundu, TK
通讯作者：
Kundu, TK
影响因子：
11
作者：
Chen G;Zhu J;Lv T;Wu G;Sun H;Huang X;Tian J
通讯作者：
Tian J