Pseudomonas aeruginosa Quorum Sensing.

Pseudomonas aeruginosa Quorum Sensing.
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DOI:
10.1007/978-3-031-08491-1_4
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发表时间:
2022
影响因子:
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中科院分区:
医学4区
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像许多细菌一样,铜绿假单胞菌在称为群体感应(QS)的过程中使用化学信号在细胞之间进行交流。QS允许细菌群体感知种群密度,并对细胞密度的变化做出反应,以协调行为。铜绿假单胞菌QS系统包括两个完整的电路,涉及酰基高丝氨酸内酯信号和第三个使用喹诺酮信号的系统。这三个QS回路共同调节数百个基因的表达,其中许多基因编码毒力因子。铜绿假单胞菌已经成为研究QS的分子生物学和细菌群体行为的生态学和进化的模型。在本章中,我们叙述了铜绿假单胞菌中QS系统的发现历史,讨论了QS与该细菌的毒力和生态的关系,并探索了抑制QS的策略。最后,我们讨论了铜绿假单胞菌未来的研究方向。
Pseudomonas aeruginosa, like many bacteria, uses chemical signals to communicate between cells in a process called quorum sensing (QS). QS allows groups of bacteria to sense population density and, in response to changing cell densities, to coordinate behaviors. The P. aeruginosa QS system consists of two complete circuits that involve acyl-homoserine lactone signals and a third system that uses quinolone signals. Together, these three QS circuits regulate the expression of hundreds of genes, many of which code for virulence factors. P. aeruginosa has become a model for studying the molecular biology of QS and the ecology and evolution of group behaviors in bacteria. In this chapter, we recount the history of discovery of QS systems in P. aeruginosa, discuss how QS relates to virulence and the ecology of this bacterium, and explore strategies to inhibit QS. Finally, we discuss future directions for research in P. aeruginosa QS.
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