Gender differences in brain functional connectivity density.

Gender differences in brain functional connectivity density.
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DOI:
10.1002/hbm.21252
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发表时间:
2012-04
影响因子:
4.8
通讯作者:
Volkow, Nora D.
Volkow, Nora D.
中科院分区:
医学2区
文献类型:
--
作者:
Tomasi, Dardo;Volkow, Nora D.

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情感、认知和社交行为的性别差异的神经基础在很大程度上是未知的。在这里,来自336名女性和225名男性的磁共振成像数据揭示了大脑功能组织的性别二态性。在五个研究地点中,女性在皮质和皮质下区域的局部功能连接密度(IFCD)比男性高14%,灰质密度比男性高5%。男性的lFCD的负功率标度比女性更陡峭,这表明大脑中强连接节点和弱连接节点之间的平衡在性别之间是不同的。男性大脑的组织比女性大脑更分散,这有助于解释认知方式和行为以及神经精神疾病患病率的性别差异(即,自闭症谱系障碍)。
The neural bases of gender differences in emotional, cognitive, and socials behaviors are largely unknown. Here, magnetic resonance imaging data from 336 women and 225 men revealed a gender dimorphism in the functional organization of the brain. Consistently across five research sites, women had 14% higher local functional connectivity density (lFCD) and up to 5% higher gray matter density than men in cortical and subcortical regions. The negative power scaling of the lFCD was steeper for men than for women, suggesting that the balance between strongly and weakly connected nodes in the brain is different across genders. The more distributed organization of the male brain than that of the female brain could help explain the gender differences in cognitive style and behaviors and in the prevalence of neuropsychiatric diseases (i.e., autism spectrum disorder).
DOI: 10.1523/jneurosci.3874-05.2006
发表时间: 2006-01-04
影响因子: 5.3
作者:
Achard, S;Salvador, R;Bullmore, ET
通讯作者: Bullmore, ET
DOI: 10.1002/hbm.20577
发表时间: 2008-07-01
影响因子: 4.8
作者:
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通讯作者: Bandettini, Peter A.
DOI: 10.1073/pnas.1001414107
发表时间: 2010-05-25
影响因子: 11.1
作者:
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通讯作者: Volkow, Nora D.
DOI: 10.1006/brln.2000.2325
发表时间: 2000-09-01
期刊: BRAIN AND LANGUAGE
影响因子: 2.5
作者:
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通讯作者: Gur, RE
DOI: 10.1016/s0730-725x(02)00503-9
发表时间: 2002-05-01
影响因子: 2.5
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通讯作者: Maravilla, K