Clinical high-resolution mapping of the proteoglycan-bound water fraction in articular cartilage of the human knee joint.
Clinical high-resolution mapping of the proteoglycan-bound water fraction in articular cartilage of the human knee joint.
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DOI：
10.1016/j.mri.2017.06.011
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发表时间：
2017-11
影响因子：
2.5
通讯作者：
Spencer RG
中科院分区：
文献类型：
--
作者：
Bouhrara M;Reiter DA;Sexton KW;Bergeron CM;Zukley LM;Spencer RG
我们应用了一种最近引入的方法来实现临床上可行的人膝关节软骨的蛋白聚糖水组分（PgWF）的体内定位，与现有方法相比具有改进的空间分辨率和稳定性。从两名健康年轻受试者和一名既往膝关节损伤的老年受试者的膝关节采集T1和T2（mcDESPOT）数据集的多组分驱动平衡单脉冲观察。每个数据集都使用贝叶斯蒙特卡罗（BMC）分析进行处理，并结合了双组分组织模型。我们评估了BMC和常规随机区域收缩（SRC）分析在估计PgWF中的性能和再现性。PgWF的BMC分析的稳定性在来自两名年轻受试者中的每一名的两个独立的高分辨率（HR）数据集中进行了测试。与SRC不同，来自两个HR数据集的BMC衍生图基本相同。此外，SRC图显示估计的PgWF存在大量随机变化，平均值与使用BMC获得的值不同。此外，PgWF地图来自传统的低分辨率（LR）数据集表现出部分体积和磁化率的影响。这些伪影在HR PgWF图像中不存在。最后，我们的分析显示PgWF估计值存在地区差异，并且年轻受试者的值远高于老年受试者。BMC-mcDESPOT允许在临床可行的采集时间内对人膝关节软骨中的PgWF进行HR体内标测。与LR标测相比，HR标测减少了部分容积和磁化率伪影的影响。最后，BMC-mcDESPOT在PgWF测定中表现出良好的重现性。
we applied a recently introduced method to achieve clinically-feasible in-vivo mapping of the proteoglycan water fraction (PgWF) of human knee cartilage with improved spatial resolution and stability as compared to existing methods. Multicomponent driven equilibrium single-pulse observation of T1 and T2 (mcDESPOT) datasets were acquired from the knees of two healthy young subjects and one older subject with previous knee injury. Each dataset was processed using Bayesian Monte Carlo (BMC) analysis incorporating a two-component tissue model. We assessed the performance and reproducibility of BMC and of the conventional analysis of stochastic region contraction (SRC) in the estimation of PgWF. Stability of the BMC analysis of PgWF was tested in two independent high-resolution (HR) datasets from each of the two young subjects. Unlike SRC, the BMC-derived maps from the two HR datasets were essentially identical. Furthermore, SRC maps showed substantial random variation in estimated PgWF, and mean values that differed from those obtained using BMC. In addition, PgWF maps derived from conventional low-resolution (LR) datasets exhibited partial volume and magnetic susceptibility effects. These artifacts were absent in HR PgWF images. Finally, our analysis showed regional variation in PgWF estimates, and substantially higher values in the younger subjects as compared to the older subject. BMC-mcDESPOT permits HR in-vivo mapping of PgWF in human knee cartilage in a clinically-feasible acquisition time. HR mapping reduces the impact of partial volume and magnetic susceptibility artifacts compared to LR mapping. Finally, BMC-mcDESPOT demonstrated excellent reproducibility in the determination of PgWF.
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