Modulation of murine bone marrow-derived CFU-F and CFU-OB by in vivo bisphosphonate and fluoride treatments.
Modulation of murine bone marrow-derived CFU-F and CFU-OB by in vivo bisphosphonate and fluoride treatments.
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通过体内双膦酸盐和氟化物处理调节小鼠骨髓来源的 CFU-F 和 CFU-OB。
DOI：
10.1111/j.1601-6343.2009.01447.x
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发表时间：
2009-05
影响因子：
3.1
通讯作者：
Everett ET
中科院分区：
文献类型：
--
作者：
Chou MY;Yan D;Jafarov T;Everett ET
双膦酸盐(BPN)对多种细胞类型有作用，包括：破骨细胞、成骨细胞、骨细胞和内皮细胞。本报告的目的是综述BPN对正畸牙移动影响的研究现状，并为BPN在体内对骨源性成骨细胞的影响提供证据。C3H/HeJ(C3H)、C57BL/6J(B6)、FVB/NJ(FVB)和BALB/cByJ(BALB)品系的小鼠分别以0、3、30或150微克/公斤/周给药。单独或与50ppm氟化物(F)混合使用。收集骨髓细胞，进行CFU-F和CFU-OB体外检测。观察4种菌株间CFU-F、CFU-OB/ALP+和CFU-OB/TOTAL的基线差异。观察了菌株对ALN和F处理的CFU-F、CFU-OB/ALP+和CFU-OB/TOTAL的特异性反应。单独用F处理后，C3H株的CFU-F(p=0.013)、CFU-OB/ALP+(p=0.005)和CFU-OB/TOTAL(p=0.003)均下降。F降低B6株CFU-F(p=0.036)。F对FVB和BALB无明显(NS)效应。ALN治疗后仅C3HCFU-F(P=0.0014)和CFU-OB/TOTAL(P=0.028)显著降低。ALN处理对4个菌株的CFU-OB/ALP+均有NS效应。遗传因素可能影响ALN对CFU-F和CFU-OB/TOTAL的影响，但对CFU-OB/ALP+的影响不大。
Bisphosphonates (BPN) have actions on a variety of cell types including: osteoclasts, osteoblasts, osteocytes, and endothelial cells. The objectives of this report are to review the current state of understanding of the effects of BPNs on orthodontic tooth movement and to provide evidence on BPN's in vivo effects on bone marrow derived osteoprogenitor cells. Mice from the C3H/HeJ (C3H), C57BL/6J (B6), FVB/NJ (FVB) and BALB/cByJ (BALB) strains were treated for 3-weeks with 0, 3, 30, or 150 mcg/kg/week alendronate (ALN) administered s.c. alone or in combination with 50ppm fluoride (F). Bone marrow cells were harvested and subjected to in vitro CFU-F and CFU-OB assays. Baseline differences in CFU-F, CFU-OB/ALP+, and CFU-OB/total were observed between the 4 strains. Strain specific responses to ALN and F treatments were observed for CFU-F, CFU-OB/ALP+, and CFU-OB/total. F treatment alone resulted in decreases in CFU-F (p = 0.013), CFU-OB/ALP+ (p = 0.005), and CFU-OB/total (p = 0.003) in the C3H strain. CFU-F (p = 0.036) were decreased by F in the B6 strain. No significant (NS) effects of F were observed for FVB and BALB. ALN treatment resulted in a significant decrease in CFU-F (p = 0.0014) and CFU-OB/total (p = 0.028) in C3H only. ALN treatment had NS effect on CFU-OB/ALP+ in all 4 strains. Genetic factors appear to play a role in ALN's effects on CFU-F and CFU-OB/total but not on CFU-OB/ALP+.
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影响因子：
4.1
作者：
Iwata, Ken;Li, Jiliang;Burr, David B.
通讯作者：
Burr, David B.
影响因子：
3.5
作者：
Ferretti, G;Fabi, A;Cognetti, F
通讯作者：
Cognetti, F
影响因子：
4.1
作者：
Frolik, CA;Bryant, HU;Chandrasekhar, S
通讯作者：
Chandrasekhar, S
影响因子：
7.6
作者：
Everett, ET;McHenry, MAK;Stookey, GK
通讯作者：
Stookey, GK
DOI：
10.1111/j.1365-2184.1987.tb01309.x
发表时间：
1987-05-01
期刊：
CELL AND TISSUE KINETICS
影响因子：
--
作者：
FRIEDENSTEIN, AJ;CHAILAKHYAN, RK;GERASIMOV, UV
通讯作者：
GERASIMOV, UV