Monoclonal antibodies to the matrix protein of vesicular stomatitis virus (New Jersey serotype) and their effects on viral transcription.
Monoclonal antibodies to the matrix protein of vesicular stomatitis virus (New Jersey serotype) and their effects on viral transcription.
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水疱性口炎病毒（新泽西血清型）基质蛋白的单克隆抗体及其对病毒转录的影响。
DOI：
10.1016/0042-6822(85)90408-8
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发表时间：
1985
期刊：
影响因子：
3.7
通讯作者：
Wagner,RR
中科院分区：
文献类型：
--
作者：
Ye,Z;Pal,R;Ogden,JR;Snyder,RM;Wagner,RR
Of 33 hybridomas raised by immunization of BALB/c mice with the matrix (M) protein of the New Jersey serotype of vesicular stomatitis virus (VSV), 17 secreted monoclonal antibodies (mAb) of the IgG isotype and, unexpectedly, 16 of the IgM isotype. All these monoclonal antibodies bound strongly to VSV-New Jersey M protein by ELISA, immunoprecipitation, and immunoblotting assays, but exhibited only slight or no cross-reactivity with the M protein of VSV-Indiana. Four antigenic determinants of VSV-New Jersey M protein could be identified by competitive binding of125I-labeled monoclonal antibodies but three of these epitopes exhibited partial overlap. Monoclonal antibodies to two epitopes reversed the inhibitory effect of M protein onin vitrotranscription of VSV-New Jersey ribonucleoprotein. However, monoclonal antibodies to the other two epitopes had little effect on M-protein transcription inhibition but actually increased significantly the transcriptional inhibitory effect of M protein under certain experimental conditions. Monoclonal antibodies to all four epitopes reacted strongly with the M protein of thetsC1 mutant of VSV-New Jersey which is restricted in transcription inhibition.
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抗体与水泡性口炎病毒主要表面糖蛋白的相互作用。
影响因子：
3.7
作者：
Leo Lefrançois;D. Lyles
通讯作者：
D. Lyles
从含有完整编码区的 cDNA 克隆确定编码水泡性口炎病毒 G 和 M 蛋白的 mRNA 的核苷酸序列
影响因子：
5.4
作者：
J. Rose;C. Gallione
通讯作者：
C. Gallione
野生型和突变型 M 蛋白水泡性口炎病毒与核衣壳的体外相互作用。
影响因子：
2.9
作者：
Wilson,T;Lenard,J
通讯作者：
Lenard,J
影响因子：
3.8
作者：
CARTWRIGHT, B;BROWN, F
通讯作者：
BROWN, F
新泽西水泡性口炎病毒血清型的 RNA 阳性互补组 C 和 D 的结构和功能特征：将 M 基因分配给 C 互补组。
影响因子：
3.7
作者：
Kennedy-Morrow,J;Lesnaw,JA
通讯作者：
Lesnaw,JA