Maternal family history of urolithiasis is associated with earlier age of onset of stone disease
Maternal family history of urolithiasis is associated with earlier age of onset of stone disease
复制标题
母亲有尿石症家族史与结石病发病年龄较早相关
DOI：
10.1007/s00345-022-04221-x
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发表时间：
2022
期刊：
影响因子：
3.4
通讯作者：
Thomas Chi
中科院分区：
文献类型：
--
作者：
Unno Rei;Taguchi Kazumi;Gregory Hosier;Manint Usawachintachit;Wilson Sui;Heiko Yang;Fadl Hamouche;David Bayne;Marshall Stoller;Thomas Chi
PurposeTo evaluate the impact of detailed family history on the severity of disease and age of onset in patients with urolithiasis. MethodsPropionate收集了2015年10月至2020年12月期间从一个单一的机构的数据进行了分析。我们的主要终点是在随访period.ResultsOf 1566例患者分析，603（39%）报告至少有一个家庭成员的结石史，至少有一个复发结石的患者人数。在8个月的中位随访期内，有结石家族史的患者（38%）发生至少一起复发性结石事件的患者百分比高于无结石家族史的患者（28%）（p= 0.001）。多因素分析显示，有尿石症家族史者结石复发的危险性增加（优势比[OR] 1.62，p < 0.001）。一级亲属和二级亲属均患有尿石症与结石复发的几率较高（OR 2.17;p= 0.003）和结石发病年龄较低（OR 3.32; < 0.001）相关。母方相对结石赋予较高的优势比为年轻的首次发病年龄的结石（OR 2.93;P< 0.001）。结论任何肾结石病家族史赋予的风险增加的复发性结石事件和早期发病年龄的尿石症。一级亲属和二级亲属或母系亲属同时患有肾结石可能是尿石症发病年龄较早的预测因素。
PurposeTo evaluate the impact of detailed family history on the severity of disease and age of onset in patients with urolithiasis.MethodsProspectively collected data from a single institution between October 2015 and December 2020 were analyzed. Our primary endpoint was the number of patients experiencing at least one recurrent stone during the follow-up period.ResultsOf 1566 patients analyzed, 603 (39%) reported at least one family member with a history of stones. The percentage of patients experiencing at least one recurrent stone event was higher in patients with a family history of stones (38%) compared to those without a family history of stones (28%) over a median follow-up period of 8 months (p= 0.001). On multivariate analysis, the presence of any family history of urolithiasis increased risk of recurrent stone events (odds ratio [OR] 1.62,p< 0.001). The presence of both a first- and a second-degree relative with urolithiasis was associated with higher odds for a recurrent stone event (OR 2.17;p= 0.003) and a younger age of onset for stones, (OR 3.32; < 0.001). A maternal-side relative with stones conferred a higher odds ratio for younger age of first onset of stones (OR 2.93;p< 0.001).ConclusionAny family history of kidney stone disease imparts an increased risk of recurrent stone event and an earlier age of onset for urolithiasis. The presence of both first- and second-degree relatives or a maternal-side relative with kidney stones may be a predictor for an earlier age of onset for urolithiasis.
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影响因子：
2.6
作者：
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通讯作者：
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影响因子：
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影响因子：
3.1
作者：
A. Guerra;A. Ticinesi;F. Allegri;A. Nouvenne;S. Pinelli;G. Folesani;F. Lauretani;M. Maggio;L. Borghi;T. Meschi
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DOI：
--
发表时间：
2013
期刊：
Pediatric nephrology (Berlin, West)
影响因子：
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作者：
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影响因子：
2.6
作者：
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通讯作者：
D. Hayes