The influence of maternal and paternal history on stone composition and clinical course of calcium nephrolithiasis in subjects aged between 15 and 25
The influence of maternal and paternal history on stone composition and clinical course of calcium nephrolithiasis in subjects aged between 15 and 25
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母亲和父亲病史对15~25岁受试者钙质肾结石结石成分和临床病程的影响
DOI：
10.1007/s00240-016-0878-5
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发表时间：
2016
期刊：
影响因子：
3.1
通讯作者：
T. Meschi
中科院分区：
文献类型：
--
作者：
A. Guerra;A. Ticinesi;F. Allegri;A. Nouvenne;S. Pinelli;G. Folesani;F. Lauretani;M. Maggio;L. Borghi;T. Meschi
我们的目的是比较母亲的结石史（MHS）和父亲的结石史（PHS）的结石成分和疾病的过程中，在一组患者的年龄在15岁至25岁的钙肾结石（CN），年龄范围与疾病表达的家族史的影响最大。从我们门诊结石诊所的数据库中回顾性选择了135例CN患者（68例F）和1例结石形成的父母，并根据MHS或PHS进行分类。通过化学分析或傅立叶变换红外分光光度法测定的结石病程和结石成分的数据，与血液化学和24小时尿结石风险的信息一起收集。采用logistic回归检验比较病程和结石成分的特征，校正年龄、性别和BMI或协方差分析（如适用）。MHS患者（n = 46）的尿钙/肌酐比值和尿铵显著高于PHS患者，泌尿外科治疗的患病率（57 vs 27%，p < 0.001）和草酸钙/磷酸钙混合结石成分（69 vs 35%，p = 0.002）高于PHS患者。在多变量logistic回归模型中，MHS与泌尿外科治疗（OR 4.5，95% CI 1.9-10.7，p < 0.001）和草酸钙/磷酸钙混合成分结石形成（OR 5.8，95% CI 1.9-17.9，p = 0.002）独立相关。石头分析的方法并不影响这一结果。总之，在15-25岁的受试者中，MHS与混合性钙结石相关，并具有较高的泌尿外科手术风险，因此，在尿石症的管理中应予以考虑。
Our aim was to compare the influence of maternal history of stones (MHS) and paternal history of stones (PHS) on composition of calculi and disease course in a group of patients with calcium nephrolithiasis (CN) aged between 15 and 25, the age range with the maximal influence of family history on disease expression. One-hundred thirty-five patients (68 F) with CN and one stone-forming parent were retrospectively selected from the database of our outpatient stone clinic, and categorized according to MHS or PHS. Data about stone disease course and composition of passed calculi, determined by chemical analysis or Fourier-transformed infrared spectrophotometry, were collected together with information on blood chemistry and 24-h urinary profile of lithogenic risk. The characteristics of disease course and stone composition were compared using logistic regression tests adjusted for age, sex, and BMI or analysis of covariance where appropriate. Patients with MHS (n = 46) had significantly higher urinary calcium/creatinine ratio and ammonium, a higher prevalence of urological treatments (57 vs 27 %, p < 0.001) and mixed calcium oxalate/calcium phosphate stone composition (69 vs 35 %, p = 0.002) than those with PHS. At multivariate logistic regression models, MHS was independently associated with urological treatments (OR 4.5, 95 %CI 1.9–10.7, p < 0.001) and the formation of calculi with mixed calcium oxalate/calcium phosphate composition (OR 5.8, 95 %CI 1.9–17.9, p = 0.002). The method of stone analysis did not affect this result. In conclusion, in subjects aged 15–25, MHS is associated with mixed calcium stones and with a higher risk for urological procedures, and should be, therefore, considered in the management of urolithiasis.
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影响因子：
19.6
作者：
Parks, JH;Coward, M;Coe, FL
通讯作者：
Coe, FL
DOI：
10.2215/cjn.08210813
发表时间：
2014-05-07
影响因子：
9.8
作者：
Lieske, John C.;Turner, Stephen T.;Kardia, Sharon L. R.
通讯作者：
Kardia, Sharon L. R.
影响因子：
19.6
作者：
Parks, JH;Worcester, EM;Lingeman, JE
通讯作者：
Lingeman, JE
DOI：
10.1016/s0022-5347(05)68665-x
发表时间：
1997-10
期刊：
Journal of the American Society of Nephrology : JASN
影响因子：
--
作者：
G. Curhan;W. Willett;E. Rimm;M. Stampfer
通讯作者：
G. Curhan;W. Willett;E. Rimm;M. Stampfer
DOI：
10.2215/cjn.05660614
发表时间：
2014-12-01
影响因子：
9.8
作者：
Lieske, John C.;Rule, Andrew D.;Moyer, Thomas P.
通讯作者：
Moyer, Thomas P.