Risk factors for urinary stones in healthy schoolchildren with and without a family history of nephrolithiasis
Risk factors for urinary stones in healthy schoolchildren with and without a family history of nephrolithiasis
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有或无肾结石家族史的健康学童发生尿路结石的危险因素
DOI：
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
G. Frontera
中科院分区：
文献类型：
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作者：
Concepción Sáez;F. Grases;D. Rodrigo;A. Garcia;Cristina Gómez;G. Frontera
研究背景结石的患病率在各个年龄段均呈上升趋势。本研究旨在评估健康学龄儿童尿液结晶风险，并确定与其最相关的尿液参数。方法采集184名5~12岁儿童的尿样：下午采集的尿样和12h的过夜尿样。获得了有关结石家族史的信息。检测尿量、pH、生化指标对结石风险的影响。结果15%的现场尿样和54%的12小时尿样观察到结晶风险。代谢异常和低尿量在有结晶风险的儿童中更常见。有结石家族史的儿童尿钙排泄量和钙/柠檬酸比值较高。结论有结石家族史的儿童尿液结晶危险的发生率较高，尤其是有家族病史的儿童。低尿量是与风险增加最相关的因素。早期摄入充足的液体可能是降低肾结石发病率的简单而有效的措施。
BackgroundThe prevalence of lithiasis is increasing at all ages. This study aimed to assess the crystallization risk in urine from healthy school children and to determine urinary parameters that are most associated with it.MethodsUrine samples were obtained from 184 children aged 5–12 years: a spot sample collected in the afternoon, and a 12-h overnight sample. Information was obtained regarding family histories of lithiasis. Urine volume, pH, and biochemical parameters of stone risk were measured. Crystallization risk was defined by the presence of specific urine conditions that had previously been associated with stone formation in vitro.ResultsCrystallization risk was observed in 15 % of spot urine samples and 54 % of 12-h samples. Metabolic abnormalities and a low urinary volume were more frequently detected in children with crystallization risk. Calcium excretion and calcium/citrate ratio were higher in children with a family history of lithiasis.ConclusionsWe observed a high prevalence of crystallization risk in urine, especially in children with a family history of the disease. Low urinary volume was the factor most associated with increased risk. Adequate fluid intake at an early age may be a simple and effective measure to reduce the incidence of nephrolithiasis.
影响因子：
13.6
作者：
Taylor, Eric N.;Curhant, Gary C.
通讯作者：
Curhant, Gary C.
影响因子：
158.5
作者：
CURHAN, GC;WILLETT, WC;STAMPFER, MJ
通讯作者：
STAMPFER, MJ
影响因子：
13.6
作者：
Taylor, Eric N.;Fung, Teresa T.;Curhan, Gary C.
通讯作者：
Curhan, Gary C.