Emerging role of human basophil biology in health and disease.
Emerging role of human basophil biology in health and disease.
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DOI：
10.1007/s11882-013-0408-2
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发表时间：
2014-01
影响因子：
5.5
通讯作者：
Huston, David P.
中科院分区：
文献类型：
--
作者：
Cromheecke, Jessica L.;Nguyen, Kathleen T.;Huston, David P.
近年来，嗜碱性粒细胞作为一种小而强大的白细胞亚群出现，能够桥接先天免疫和适应性免疫。它们可以通过 IgE 依赖性和 IgE 独立机制被激活，释放预先形成的介质并产生 Th2 细胞因子。除了在蠕虫的保护性免疫中发挥作用外，嗜碱性粒细胞还是各种过敏反应的主要参与者，包括过敏反应和速发型超敏反应、迟发性超敏反应和迟发性超敏反应。此外，嗜碱性粒细胞还与狼疮性肾炎和类风湿性关节炎等自身免疫性疾病的病理生理学以及对细菌感染的免疫反应的调节有关，并且是髓性白血病的一个特征。激活、脱粒、跨内皮迁移和免疫调节的独特信号正在被定义，并证明嗜碱性粒细胞在促进 Th2 微环境中的重要作用。这些机制见解正在推动嗜碱性粒细胞诊断测试和治疗靶向的创新方法。
Basophils have emerged in recent years as a small but potent subpopulation of leukocytes capable of bridging innate and adaptive immunity. They can be activated through IgE-dependent and IgE-independent mechanisms to release preformed mediators and to produce Th2 cytokines. In addition to their role in protective immunity to helminths, basophils are major participants in allergic reactions as diverse as anaphylaxis and immediate hypersensitivity reactions, late-phase hypersensitivity reactions, and delayed hypersensitivity reactions. Additionally, basophils have been implicated in the pathophysiology of autoimmune diseases such as lupus nephritis and rheumatoid arthritis, and the modulation of immune responses to bacterial infections, as well as being a feature of myelogenous leukemias. Distinct signals for activation, degranulation, transendothelial migration, and immune regulation are being defined, and demonstrate the important role of basophils in promoting a Th2 microenvironment. These mechanistic insights are driving innovative approaches for diagnostic testing and therapeutic targeting of basophils.
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影响因子：
14.2
作者：
Ford, Lara S.;Bloom, Katherine A.;Nowak-Wegrzyn, Anna H.;Shreffler, Wayne G.;Masilamani, Madhan;Sampson, Hugh A.
通讯作者：
Sampson, Hugh A.
影响因子：
82.9
作者：
通讯作者：
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影响因子：
14.2
作者：
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通讯作者：
Hausmann, Oliver V.
影响因子：
4.4
作者：
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通讯作者：
Cambier, John C.
影响因子：
15.3
作者：
DVORAK, HF;MIHM, MC
通讯作者：
MIHM, MC