Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects.

Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects.
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自杀受害者大脑中的血清素测量:自杀受害者和对照受试者额叶皮层中的 5-HT2 结合位点。

DOI:
10.1176/ajp.146.6.730
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发表时间:
1989
期刊:
The American journal of psychiatry
影响因子:
--
通讯作者:
Meltzer,HY
Meltzer,HY
中科院分区:
--
文献类型:
--
作者:
Arora,RC;Meltzer,HY

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作者确定了 32 名自杀受害者和 37 名死于非精神原因的受试者额叶皮层中血清素 2 (5-HT2) 的结合情况。自杀受试者的最大结合位点数量(Bmax)和亲和力(Kd)显着高于对照组。然而,在年龄、种族、性别和死后延迟的影响共变后,这两组之间的 Kd 没有差异。暴力自杀的受试者的 Bmax 显着高于对照组。
The authors determined serotonin2 (5-HT2) binding in the frontal cortex of 32 suicide victims and 37 subjects who died from nonpsychiatric causes. The maximum number of binding sites (Bmax) and the affinity (Kd) were significantly higher in subjects who had committed suicide than in control subjects. However, there was no difference in Kd between these two groups after the influence of age, race, sex, and postmortem delay was covaried. The Bmax of subjects who had committed violent suicide was significantly greater than that of control subjects.
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