Anthelmintic efficacy of Santalum album (Santalaceae) against monogenean infections in goldfish

Anthelmintic efficacy of Santalum album (Santalaceae) against monogenean infections in goldfish
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檀香(檀香科)对金鱼单殖感染的驱虫功效

DOI:
10.1007/s00436-013-3455-7
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发表时间:
2013-05
影响因子:
2
通讯作者:
Wang Gaoxue
Wang Gaoxue
中科院分区:
医学3区
文献类型:
--
作者:
Ling Fei;Huang Aiguo;Zhang Qizhong;Wang Gaoxue

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指环虫属和三代虫属(Gyrodactylus spp.)是对水产养殖业构成重大威胁的蠕虫体外寄生虫。现有的治疗方法可能会导致驱虫药耐药性的威胁,残留的风险,环境污染和鱼类的毒性。重要的是,没有关于针对这两种寄生虫的治疗的报道。本研究探讨檀香提取物治疗金鱼指环虫和三代虫感染的可能性。结果表明,在S.氯仿提取物的效果最好,40 mg/L是安全的最低有效剂量。此外,我们发现,当暴露于药用植物提取物时,雅致三代虫比中间指环虫更敏感。最后,证实了长时间和多次给药的沐浴治疗可以消除更大比例的单殖吸虫感染。这些发现显示了开发有效和安全的治疗鱼类指环虫属和三代虫属感染的疗法的潜力。
Dactylogyrus spp. and Gyrodactylus spp. are helminth ectoparasites that are a significant threat to the aquaculture industry. Existing treatments could cause the threats of anthelmintic resistance, risk of residues, environmental contamination, and toxicity to fish. Importantly, there is no report on a treatment against these two parasites. This study explored the possibility of using the extracts of Santalum album to treat Dactylogyrus sp. and Gyrodactylus sp. infections in goldfish. Results showed that among the four extracts (chloroform, methanol, ethyl acetate, and water) of S. album, the chloroform extract is the most effective and 40 mg/L is a safe and the lowest effective dosage. In addition, we found that Gyrodactylus elegans is more sensitive than Dactylogyrus intermedius when exposed to the extract of the medicinal plant. Finally, it is substantiated that bath treatment with long duration and multiple administrations could eliminate a greater proportion of monogenean infections. These findings show the potential for the development of effective and safe therapy to treat Dactylogyrus sp. and Gyrodactylus sp. infections of fishes.
DOI: 10.1007/s00436-010-2211-5
发表时间: 2011-06-01
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期刊: ZEITSCHRIFT FUR PARASITENKUNDE-PARASITOLOGY RESEARCH
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