The association between vitamin D and uterine fibroids: A mendelian randomization study.
The association between vitamin D and uterine fibroids: A mendelian randomization study.
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DOI：
10.3389/fgene.2022.1013192
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发表时间：
2022
影响因子：
3.7
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中科院分区：
文献类型：
--
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子宫肌瘤是最常见的妇科良性肿瘤，严重影响妇女的生活质量。维生素D被认为在调节细胞增殖和分化中起重要作用。近年来，一些研究表明，较高水平的维生素D对UFs的发生有负面影响，但它们之间的关系的研究结果是相互矛盾的，需要进一步的证据进行研究。在本文中，我们使用了一项双样本孟德尔随机化（2SMR）研究来探索遗传预测的维生素D水平与UFs风险之间的因果关系。暴露数据来自全基因组关联研究（GWAS）汇总数据集，包括441，291名个体，其中包括来自英国生物银行，FinnGen生物银行和相应联盟的数据集。选择与维生素D相关的单核苷酸多态性（SNP），其显著性水平为p < 5 × 10−8和低连锁不平衡（LD）水平（r2 < 0.01）。结果数据来自英国生物库表型IEU分析的GWAS数据集，包括7，122例UF病例和455，811例对照。我们的逆方差权重（IVW）分析结果支持遗传预测的维生素D与UFs风险的因果关系（OR = 0.995，95%CI = 0.990-0.999，p = 0.024）。此外，在统计模型中未观察到异质性和多效性。总之，我们的研究结果表明，血清维生素D水平升高与降低UFs的风险密切相关，这表明UFs的临床治疗可能有一个新的和优秀的选择。
Uterine fibroids (UFs), the most common benign gynecological tumor, can bring severe negative impacts on a woman’s life quality. Vitamin D, is thought to play an important role in regulating cell proliferation and differentiation. In recent years, several studies suggested that higher level of vitamin D has a negative effect on the occurrence of UFs, but the results of studies on the relationship between them are conflicting and further evidence needs to be studied. Here in, we used a two-sample Mendelian Randomization (2SMR) study to explore the causal relationship between genetically predicted vitamin D levels and the risk of UFs. The exposure data comes from a genome-wide association study (GWAS) summary dataset consisting of 441,291 individuals, which includes datasets from United Kingdom Biobank, FinnGen Biobank and the corresponding consortia. Single-nucleotide polymorphisms (SNPs) associated with vitamin D at a significant level of p < 5 × 10−8 and low linkage disequilibrium (LD) level (r2 < 0.01) were selected. The outcome data comes from a GWAS dataset of IEU analysis of United Kingdom Biobank phenotypes consisting of 7,122 UFs cases and 455,811 controls. Our inverse-variance weight (IVW) analysis results support the causal association of genetically predicted vitamin D with the risk of UFs (OR = 0.995,95% CI = 0.990-0.999, p = 0.024). In addition, heterogeneity and pleiotropy were not observed in statistical models. In summary, our results indicate that elevated serum vitamin D levels are in strong relationship with reduction of the risk of UFs, which indicates that the clinical treatment of UFs may have a new and excellent option.
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