Effects of image noise in muscle diffusion tensor (DT)-MRI assessed using numerical simulations.

Effects of image noise in muscle diffusion tensor (DT)-MRI assessed using numerical simulations.
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DOI:
10.1002/mrm.21707
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发表时间:
2008-10
影响因子:
3.3
通讯作者:
Damon, Bruce M.
Damon, Bruce M.
中科院分区:
医学3区
文献类型:
--
作者:
Damon, Bruce M.

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骨骼肌的扩散张量MRI(DT-MRI)研究提供了有关肌肉结构、微观结构和损伤的信息。然而,噪声、扩散加权(B-)值和部分体积伪影对扩散张量(D)估计的影响是未知的。本研究使用Monte Carlo模拟包含肌肉、脂肪组织和中等程度肌肉体积分数(fM)的3×9体素感兴趣区域来研究这些问题。针对8个b值和11个SNR水平中的每一个进行1000次模拟。观察了本征值(λ1-3)、平均扩散率(λ)、分数各向异性(FA)和第一本征向量与其真值的角偏差(α)的依赖性。对于中等b值(B=435-725 s/mm 2)和fM=1,在SNR为25的情况下,λ1-3和FA的准确度为5%。在fM=1和SNR=50的情况下,对于λ1-3,和FA,获得了1%的准确度。对于fM=8/9的区域,在SNR=40的情况下获得5%的准确度。对于α,对于fM=1和fM=0.5的±4.5°不确定性,分别要求SNR≥25和≥45;对于单个肌肉体素的±9°不确定性,要求SNR≥60。这些发现可能会影响肌肉微观结构,损伤和结构的DT-MRI研究的设计和解释。
Diffusion-tensor MRI (DT-MRI) studies of skeletal muscle provide information about muscle architecture, microstructure, and damage. However, the effects of noise, the diffusion weighting (b-) value, and partial volume artifacts on the estimation of the diffusion tensor (D) are unknown. This study investigated these issues using Monte Carlo simulations of 3×9 voxel regions of interest containing muscle, adipose tissue, and intermediate degrees of muscle volume fractions (fM). 1000 simulations were performed for each of 8 b-values and 11 SNR levels. The dependences of the eigenvalues (λ1-3), mean diffusivity ( ), fractional anisotropy (FA), and the angular deviation of the first eigenvector from its true value (α) were observed. For moderate b-values (b=435-725 s/mm2) and fM=1, an accuracy of 5% was obtained for λ1-3, , and FA with an SNR of 25. An accuracy of 1% was obtained for λ1-3, , and FA with fM=1 and SNR=50. For regions with fM=8/9, 5% accuracy was obtained with SNR=40. For α, SNR≥25 and ≥45 were required for ±4.5° uncertainty with fM=1 and fM=0.5, respectively; SNR≥60 was required for ±9° uncertainty in single muscle voxels. These findings may influence the design and interpretation of DT-MRI studies of muscle microstructure, damage, and architecture.
DOI: 10.1007/s00421-004-1186-2
发表时间: 2004-12-01
影响因子: 3
作者:
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通讯作者: Ladd, ME
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发表时间: 1972-01-01
期刊: BIOCHIMICA ET BIOPHYSICA ACTA
影响因子: --
作者:
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DOI: 10.1002/mrm.10198
发表时间: 2002-07-01
影响因子: 3.3
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